摘要
免疫性血小板减少症(ITP)是由于血小板破坏增加或生成减少导致外周血血小板的减少,引起皮肤、黏膜及内脏出血等临床表现为特点的常见出血性疾病。ITP的发病机制迄今为止尚未得到完全阐明,积极探索本病的发病机制,不仅具有重要的理论意义,而且可能为本病的治疗提供新的策略。微小RNA(microRNA,miRNA)是一类长度约为19～22个核苷酸的小分子非编码RNA,通过调控其靶基因,参与多种疾病的发生和发展。目前miRNA在ITP发病机制中的研究越来越广泛,本文就近年来针对miRNA在ITP发病机制中的研究进展做一综述。
Immune thrombocytopenia （ITP）, one of the most common bleeding disorders, is characterized by clinical manifestations of skin mueosa and internal bleeding and by decreased platelet count due to auto-antibody mediating the platelets destruction and insufficient platelet production. The exact etiology of ITP is still unclear so far. To fully understand the pathogenesis of ITP not only has imporlant theoretical significance but also may provide a new strategy for the treatment of the disease. MieroRNA （miRNA） is a class of small non-coding RNAs with a length of 19-22 nueleotides. It is involved in the occurrence and development of many diseases by regulating its target genes. At present, there are more and more studies on the role of mieroRNAs in the pathogenesis of ITP. In this review, the progress of miRNA in the pathogenesis of ITP in recent years was summarized.
作者
赵海丰
阚育田
王鑫源
张翼鷟
ZHAO Hai-feng;KAN Yu-tian;WANG Xin-yuan;ZHANG Yi-zhuo(Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin Clinical Research Center for Cancer,Tianjin 300060,China)
出处
《天津医药》
CAS
北大核心
2018年第10期1131-1134,共4页
Tianjin Medical Journal
基金
国家自然科学基金资助项目(81100337,81470283,81570201)
