摘要
目的对比关节腔内注射脐带血间充质干细胞与滑膜源间充质干细胞治疗膝关节软骨损伤的疗效。方法采用回顾性、随机抽样与对照研究方法,选择2013年9月至2016年8月诊治的48例膝关节软骨损伤患者作为研究对象,按照采取的不同治疗方法划分为对照组和观察组,各24例,对照组给予注射脐带血间充质干细胞治疗,观察组给予注射滑膜间充质干细胞治疗,观察两组临床疗效、膝关节Lequesne指数评分、疼痛评分及并发症情况。结果治疗后6个月观察组和对照组的优良率分别是95. 8%与66. 7%,观察组的优良率显著高于对照组(P <0. 05)。治疗后观察组与对照组的Lequesne指数评分分别为(86. 35±11. 34)分、(75. 85±10. 74)分,显著高于治疗前的(56. 25±12. 54)分和(56. 25±9. 11)分(P均<0. 01),且观察组治疗后评分高于对照组(P <0. 01)。而且经过治疗,观察组视觉疼痛量表评分(VAS)也优于对照组[(2. 11±1. 54)分vs (3. 61±1. 44)分,P <0. 01]。治疗后观察组的血栓栓塞、肺部感染、下肢肿胀等并发症发生率为8. 3%,对照组为25. 0%,观察组低于对照组,但差异无统计学意义(P> 0. 05)。结论相对于脐带血间充质干细胞,滑膜间充质干细胞在膝关节软骨损伤治疗中的应用能更好改善膝关节功能,缓解疼痛,安全性高。
Objective To compare the therapeutic effects of intra-articular injection of umbilical cord blood mesenchymal stem cells and of synovial-derived mesenchymal stem cells in treatment of articular cartilage injury of knee joint. Methods Using a retrospective,random sampling and control study method,48 patients with knee articular cartilage injury from September 2013 to August 2016 were selected as the research objects. According to the different treatment methods,the patients were divided into the control group and the observation group（n = 24,each）. The umbilical cord blood mesenchymal stem cell therapy was given in control group,and synovial mesenchymal stem cell therapy was given in observation group. The clinical efficacy,Lequesne index score of knee joint,visual analog scale（VAS） and complications were observed and compared between two groups. Results The excellent rate in observation group was significantly higher than that in control group 6 months after treatment（95. 8% vs 66. 7%,P〈0. 05）. After treatment,the Lequesne index scores in observation group [（86. 35 ± 11. 34） points vs（56. 25 ± 12. 54） points]and in control group[（75. 85 ± 10. 74）points vs（56. 25 ± 9. 11） points] were significantly higher than those before treatment,and the score in observation group was significantly higher than that in control group（all P〈0. 01）. After treatment,VAS score in observation group was significantly lower than that in control group [（2. 11 ± 1. 54） points vs（3. 61 ± 1. 44） points,P〈0. 01]. The incidence of complications such as thromboembolism,pulmonary infection and lower extremity swelling was 8. 3% in observation group and 25. 0% in control group,there was no statistical difference between two groups even though the incidence of complications was lower in observation group（P〈0. 05）. Conclusion Compares with umbilical cord blood mesenchymal stem cells,synovial mesenchymal stem cells can improve the function of knee joint,relieve pain and have higher safety in the treatment of knee joint cartilage injury.
作者
陈子秋
刘顺贵
刘义
龚泰芳
CHEN Zi-Qiu , LIU Shun-Gui, LIU Yi, GONG Tai-Fang(The Fifth Ward of Orthopedics Department, Taihe Hospital Affiliated to Hubei Medicine University, Shiyan, Hubei 442000, China)
出处
《中国临床研究》
CAS
2018年第9期1232-1235,共4页
Chinese Journal of Clinical Research
关键词
脐带血
滑膜
间充质干细胞
膝关节
软骨损伤
Umbilical cord blood
Synovial membrane
Mesenchymal stem cells
Knee joint
Cartilage injury
