摘要
目的回顾分析对儿童支气管哮喘合并变应性鼻炎采用白三烯受体拮抗剂治疗的临床效果,总结临床经验。方法选取该院在2016年2月—2018年2月期间共收治的96例儿童支气管哮喘合并变应性鼻炎患儿作为研究对象,按照用药不同将其分为两组,研究组和对照组患儿各48例。其中研究组患儿采取吸入布地奈德气雾剂加孟鲁司特治疗,对照组患儿仅采取布地奈德气雾剂吸入治疗,比较两组患儿临床治疗效果。结果治疗后,研究组患儿FEV1值(119.02±13.28)%高于对照组的(103.86±14.98)%,而鼻外周EOS值(10.48±21.51)%明显低于对照组(21.79±24.97)%,差异有统计学意义(FEV1:t=5.246 6,P=0.000 0 <0.05;EOS:t=2.377 6;P=0.019 5<0.05);且研究组患儿使用速效β_2受体激动剂次数[(0.36±0.49)分/周]、药物分值[(1.60±2.30)分/周]明显低于对照组(1.38±2.91)分/周,(7.61±11.22)分/周],差异都有统计学意义(β_2受体激动剂次数:t=2.394 7,P=0.018 6 <0.05;药物分值:t=3.635 5,P=0.000 5<0.05)。结论儿童支气管哮喘合并变应性鼻炎行白三烯受体拮抗剂治疗,能够有效地缓解患儿临床症状,改善肺功能,减少哮喘急性发作,效果良好。
Objective To retrospectively analyze the clinical effects of leukotriene receptor antagonist therapy in children with bronchial asthma complicated with allergic rhinitis and summarize clinical experience. Methods 96 children with bronchial asthma complicated with allergic rhinitis were enrolled in the hospital from February 2016 to February 2018. The patients were divided into two groups according to different medications. The study group and the control group were divided into two groups. There were 48 children in each case. The children in the study group were treated with inhaled budesonide aerosol plus montelukast. The children in the control group were only treated with budesonide aerosol inhalation, and the clinical effects of the two groups were compared. Results After treatment, the FEV1 value of the study group （119.02±13.28）% was higher than that of the control group （103.86±14.98）%, while the nasal peripheral EOS value（10.48±21.51）% was significantly lower than that of the control group（21.79±24.97）%. Statistically significant （FEV1： t=5.246 6, P=0.000 0 〈0.05; EOS： t=2.377 6; P=0.019 5 〈0.05）; and the number of fast-acting β2 receptor agonists in the study group [（0.36±0.49）times/week], the drug score[（1.60±2.30）minutes/week] was significantly lower than the control group [（1.38±2.91）times/week,（7.61±11.22）points/week], the difference was statistically significant （beta 2 re ceptor agonist times： t= 2.394 7, P=0.018 6〈0.05; drug score： t=3.635 5, P=0.000 5〈0.05）. Conclusion Children with bronchial asthma and allergic rhinitis treated with leukotriene receptor antagonist can effectively alleviate the clinical symptoms, improve lung function and reduce acute asthma attack.
作者
王正军
纪建兵
苏宝凤
康云峰
缪伶伶
WANG Zheng-jun;JI Jian-bing;SU Bao-feng;KANG Yun-feng;MIAO Ling-ling(Department of Pediatrics,Rugao People＇s Hospital,Rugao,Jiangsu Province,226500 China;Nanjing Hospital Affiliated to Nanjing Medical University（First Hospital of Nanjing,Jiangsu province）,Nanjing,Jiangsu Province,210006 China)
出处
《系统医学》
2018年第17期119-121,共3页
Systems Medicine
关键词
儿童支气管哮喘
变应性鼻炎
白三烯受体拮抗剂
Childhood bronchial asthma
Allergic rhinitis
Leukotriene receptor antagonist
