摘要
目的制备齐墩果酸固体分散体。方法共沉淀法制备固体分散体后,以累积溶出度为评价指标,复合载体(PVP k30、Soluplus)比例、药物与复合载体比例为影响因素筛选处方。然后,通过X射线衍射(XRD)、扫描电子显微镜(SEM)、红外光谱(IR)、差示扫描量热(DSC)进行表征。结果最佳处方为复合载体比例1∶2,药物与复合载体比例为1∶7,固体分散体在120 min内的累积溶出度达87%。齐墩果酸以无定形状态高度分散在复合载体中。结论复合载体制备的固体分散体可明显提高齐墩果酸溶出行为。
AIM To prepare the oleanolic acid solid dispersions. METHODS For the solid dispersions pre- pared by co-precipitation method, the formulation was screened with accumulative dissolution rate as an evaluation index, and composite carrier （PVP k30, Soluplus） ratio, drug-composite carrier ratio as influencing factors. Then characterization was performed by X-ray diffraction （XRD）, scanning electron microscope （SEM）, infrared spec- troscopy （IR） and differential scanning calorimewy （DSC）. RESULTS The optimal formulation was determined to be 1 ： 2 for composite carrier ratio, and 1 ： 7 for drug-composite carrier ratio, the solid dispersions＇ accumula- tive dissolution rate reached 87% within 120 min. Oleanolic acid was highly dispersed in composite carrier in an amorphous state. CONCLUSION The solid dispersions prepared by composite carrier can obviously improve the dissolution behaviors of oleanolic acid.
作者
赵强
武倩
刘喜纲
ZHAO Qiang;WU Qian;LIU Xi-gang(Hebei Provincial Key Laboratory for Research and Development of Chinese Medicin;Institute for Chinese Materia Medics,Chengde Medical University Chengde 067000,China)
出处
《中成药》
CAS
CSCD
北大核心
2018年第10期2170-2176,共7页
Chinese Traditional Patent Medicine
基金
河北省高等学校科学技术研究项目(QN2018057)
河北省高校重点学科建设项目(冀教高[2013]4)
关键词
齐墩果酸
固体分散体
制备
共沉淀法
oleanolic acid
solid dispersions
preparation
co-precipitation method
