摘要
目的探讨丁苯酞联合健脑益智汤对脑梗死患者的影响。方法选取2016年7月—2017年8月华中科技大学同济医学院附属武汉中心医院收治的脑梗死患者90例,采用随机数字表法分为对照组和观察组,每组45例。在常规对症治疗基础上,对照组患者予以丁苯酞治疗14 d,观察组患者在对照组基础上予以健脑益智汤治疗14 d。比较两组患者临床疗效,治疗前后Barthel指数(BI)评分、美国国立卫生研究院卒中量表(NIHSS)评分、大脑中动脉血流动力学指标及血清人软骨糖蛋白39(Hc-gp39)、超敏C反应蛋白(hs-CRP)水平,并观察两组患者治疗期间不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者BI评分、NIHSS评分比较,差异无统计学意义(P>0.05);治疗后观察组患者BI评分高于对照组,NIHSS评分低于对照组(P<0.05)。治疗前两组患者大脑中动脉平均峰流速(Vm)、收缩期峰流速(Vs)、舒张期峰流速(Vd)比较,差异无统计学意义(P>0.05);治疗后观察组患者大脑中动脉Vm、Vs、Vd快于对照组(P<0.05)。治疗前两组患者血清Hc-gp39、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清Hc-gp39、hs-CRP水平低于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论丁苯酞联合健脑益智汤可有效提高脑梗死患者临床疗效,改善患者日常生活能力、神经功能及大脑中动脉血流动力学,降低血清Hc-gp39、hs-CRP水平,且未增加不良反应发生风险。
ObjectiveTo investigate the impact of butyphthalide combined with jiannao-yizhi decoction on patients with cerebral infarction. MethodsFrom July 2016 to August 2017,a total of 90 patients with cerebral infarction were selected in Wuhan Central Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,and they were divided into control group and observation group according to random number table,each of 45 cases. Based on conventional symptomatic treatment,patients in control group received butyphthalide for 14 days,while patients in observation group received jiannao-yizhi decoction for 14 days based on that of control group. Clinical effect,Barthel index,NIHSS score,hemodynamic index of middle cerebral artery（MCA）,serum levels of Hc-gp39 and hs-CRP before and after treatment were compared between the two groups,and incidence of adverse reactions was observed during treatment. ResultsClinical effect in observation group was statistically significantly better than that in control group（P〈0.05）. No statistically significant differences of Barthel index or NIHSS score was found between the two groups before treatment（P〉0.05）;after treatment,Barthel index in observation group was statistically significantly higher than that in control group, while NIHSS score in observation group was statistically significantly lower than that in control group （P〈0.05） . No statistically significant differences of mean peak velocity （Vm） , systolic peak velocity （Vs） or diastolic peak velocity （Vd）of MCA was found between the two groups before treatment（P〉0.05）,while Vm,Vs and Vd of MCA in observation group were statistically significantly faster than those in control group after treatment,respectively（P〈0.05）. No statistically significant differences of serum level of Hc-gp39 or hs-CRP was found between the two groups before treatment P〉0.05while serum levels of Hc-gp39 and hs-CRP in observation group were statistically significantly lower than those in control group（P〈0.05）. No statistically significant differences of incidence of adverse reactions was found between the two groups during treatment（P〉0.05）. ConclusionButyphthalide combined with jiannao-yizhi decoction can effectively improve the clinical effect,activity of daily living,neurological function and haemodynamics of MCA,reduce the serum levels of Hc-gp39 and hs-CRP without increasing the risk of adverse reactions.
作者
章文慧
李娜
ZHANGWen-hui;LI Na(Department of Neurology,Wuhan Central Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430000,China)
出处
《实用心脑肺血管病杂志》
2018年第8期53-56,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
脑梗死
丁苯酞
健脑益智汤
治疗结果
Brain infarction
Butylphthalide
Jiannao-yizhi decoction
Treatment outcome
