摘要
目的:探讨组织细胞坏死性淋巴结炎(HNL)的中医证型分布及发病特征。方法:收集166例HNL患者临床资料,进行统计分析。结果:166例中,男:女=1:3.37,其中风热痰毒证96例(57.83%)、热毒壅盛证57例(34.34%)、痰瘀互结证13例(7.83%);主要临床体征分布为,淋巴结肿大166例(100%)、伴疼痛143例(86.15%)、发热61例(36.75%),白细胞计数(WBC)减少81例(48.80%)、血沉(ESR)升高69例(41.57%)、乳酸脱氢酶(LDH)升高48例(28.92%)、谷丙转氨酶(ALT)及谷丙转氨酶(AST)升高者41例(25.30%)。其中风热痰毒证流感症状较为集中、WBC正常及轻度减少为主;热毒壅盛证淋巴结肿痛、发热更明显,皮疹、关节酸痛、肝脾肿大更多见,WBC中重度减少、肝功能明显异常、ESR及LDH升高者多见(P<0.05)。结论:HNL中医证型以风热痰毒证、热毒壅盛证多见,热毒壅盛证临床症状及实验室异常指标最严重,需要引起重视。
Objective To observe the characteristics and traditional Chinese medicine （TCM） syndrome type distribution of histiocytic necrotizing lymphadenitis （HNL）. Methods HNL inpatients （166 cases） were collected from March 2016 to September 2017, and statistical analysis was performed. Results Of 166 cases （male vs female 1：3.37）, 96 cases （57.83%） were wind-heat phlegm-toxin syndrome, 57 cases （34.34%） were heat-toxin obstruction syndrome and 13 cases （7.83%） were phlegm-blood stasis syndrome. The main clinical signs were as follows： 100% （166 cases） of the patients were with lymphadenopathy, 86.15% （143 cases） with pain, 36.75 % （61 cases） with fever, 48.80% with leukopenia, 41.57% （81 cases） with elevated erythrocyte sedimentation rate, 28.92% （48 cases） with elevated serum lactate dehydrogenase and 25.30% （41 cases） with elevated serum alanine aminotransferase. The symptoms of wind heat phlegm poisoning were concentrated. WBC was mainly normal and mildly decreased. The symptoms of heat toxin accumulation were as follows： swollen and pain in the lymph nodes and fever were obvious, skin rash, joint pain and hepatomegaly were more common. WBC moderate severe reduction, abnormal liver function, elevated ESR and LDH were common.Conclusion The wind-heat and phlegm-toxin syndrome and heat-toxin exuberance syndrome have the highest incidence in HNL. The clinical symptoms and laboratory abnormality index of heat toxin accumulation syndrome axe the most serious and need to be paid attention to.
作者
薛倩一
靳汝辉
黄子慧
傅良杰
丁继果
金全永
XUE Qian-yi;JIN Ru-hui;HUANG Zi-hui(Department of Luoli,Nanjing Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing（210014）,China)
出处
《中国中西医结合外科杂志》
CAS
2018年第5期533-536,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
江苏省"十二五"中医重点学科建设项目(苏中医政[2013]30号)
南京市科技计划资金资助项目(201715056)
南京市医学科技发展资金资助项目(YKK15173
YKK16212)
南京市转化医学中心基地建设项目(宁卫规财[2013]77号)
第六批全国老中医药专家学术经验继承项目(钮晓红)(国中医药人教发[2017]29号)
南京市名中医工作室(钮晓红
夏公旭)(宁卫中医[2017]8号)
关键词
坏死性淋巴结炎
中医证型
发病特征
Histiocytic necrotizing lymphadenitis
traditional Chinese Medicine syndrome type
characteristics
