摘要
通过摩尔配比法,应用槲皮素与新戊酸铜合成新型配合物;通过元素分析、红外以及热重法对配合物进行分析;采用MTT法体外实验研究配合物对肝癌细胞Hep3B的抗肿瘤活性。结果表明摩尔配比法得到两种铜和槲皮素的配合物。MTT实验显示配合物对肝癌细胞Hep3B具有明显的抑制作用。
New complexes were obtained by mixing different molar ratios of quercetin and copper pivalate. The complexes were analyzed by elemental analysis, infrared spectrometry and thermogravimetry, and were investigated antitumor activity against cancer cell line Hep3B via MTT method in vitro. The results showed that two copper complexes were obtained by adjusting molar ratios of quereetin and copper pivalate. MTT assay showed that quereetin copper complexes have stronger inhibition effects on Hep3B cancer cell than quereetin.
作者
王继群
张雷
刘丽敏
张雨晴
艾莉蒳
李婧
Wang Jiqun;Zhang Lei;Liu Limin;Zhang Yuqing;Yi Lina;Li Jing(College of Life Science and Biotechnology,Heilongjiang Bayi Agriculture University,Daqing 163319,China)
出处
《山东化工》
CAS
2018年第19期18-20,共3页
Shandong Chemical Industry
基金
黑龙江八一农垦大学青年创新人才基金(CXRC2016-13)
黑龙江省大学生创新创业项目(201810223080)
关键词
槲皮素
金属配合物
抗肿瘤活性
quercetin
metal complex
anti - tumor activity
