摘要
重组人干扰素α1b（IFNα1b）作为中国第一个基因工程Ⅰ类新药，具有独特的生物学意义及临床价值。特别是在儿科领域，IFNα1b用于小儿病毒性肺炎、病毒性肝炎、毛细支气管炎、疱疹性咽峡炎、手足口病和某些肿瘤的治疗，均显示了确切的疗效和良好的安全性，近期在病毒相关的喘息性疾病、流感等重大传染病防治领域展现了更大的应用前景，为促进我国儿童健康发挥了重要作用。现就IFNα1b的基因和分子特点、新型递送方式及儿童应用的前沿研究成果进行阐述和讨论。
As the first class Ⅰ novel genetic engineering medical product in China, recombinant human interferon alpha 1b （IFNα1b） shows unique biological significance and clinical value.Especially in the field of pediatrics, IFNα1b has been used in the treatment of viral pneumonia, viral hepatitis, bronchiolitis, herpetic angina, hand-foot-mouth disease and some tumors in children and shown definite efficacy and good safety.It is also used in the prevention and treatment of virus-related wheezing and major infectious diseases, such as influenza.With a greater application prospect, IFNα1b plays an important role in promoting children′s health in China.Now, IFNα1b′s gene and molecular characteristics, new delivery methods, and the frontier clinical research will be discussed.
作者
侯云德
张国成
Hou Yunde;Zhang Guocheng(National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beifing 102206,China（Hou YD;Children＇s Hospital,China Armed Police Service School of Medicine,Tianjin 300163,China（Zhang GC)
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2018年第18期1361-1365,共5页
Chinese Journal of Applied Clinical Pediatrics
