摘要
目的:验证Lymphocyte antigen 6 complex,locus E (LY6E)的表达与胃癌放疗敏感性有联系的这一假设。方法:采用TCGA数据库中公开的胃癌数据,将胃癌的数据随机地分为两部分,一份作为测试数据,另一份作为验证数据。以P值为0. 05作为显著性判断标准。结果:LY6E的表达对于胃癌患者的总生存无明显联系;在测试和验证数据中,LY6E高表达的胃癌患者在放疗与非放疗两组间的总生存差异无统计学意义(P>0. 05),多因素调整后仍然无统计学意义(P> 0. 05)。多因素调整后,验证数据与测试数据的HR值分别为0. 72(0. 29-1. 76)和1. 28(0. 47-3. 47),P值为0. 47和0. 63;另一方面,在LY6E低表达的胃癌患者中,放疗组的生存率比非放疗组有着明显的提高,验证数据与测试数据的HR值调整后为0. 05(0. 005-0. 46)和0. 06(0. 01-0. 36),P值为8. 39*10-3和2. 36*10-3。结论:低表达的LY6E与胃癌放疗敏感性有明显的关联,LY6E低表达的患者接受放疗后生存率明显升高,表明LY6E是胃癌精准放疗的潜在的有效分子标记物。
Objective To verify- the hypothesis that Lymphocyte antigen 6 complex, locus E （LY6E） expression is associat- ed with radiosensitivity of gastric cancer. Method Gastric cancer data published in TCGA database were randomly divided into two parts, one as test data and the other as validation data. The P value was 0. 05 as the criterion of significance. Result- s There was no significant correlation between LY6E expression and total survival of patients with gastric cancer. In the test and validation data, there was no significant difference between radiotherapy and non - radiotherapy in total survival of patients with gastric cancer （P 〉 0. 05）. After multivariate adjustment, the HR values of validation data and test data were 0. 72 （0. 29 - 1.76） and 1.28 （0.47 -3.47） , P values were 0.47 and 0. 63, respectively. On the other hand, the survival rate of radio- therapy group was significantly higher than that of non - radiotherapy group, and the HR values of validation data and test data were0.05 （0.005 - 0.46） after adjustment. And 0.06 （0.01 - 0.36）, P value 8.39 x 103 and 2. 36 x 10 3. Conclusion Low expression of LY6E is significantly associated with radiosensitivity of gastric cancer. The survival rate of pa- tients with low expression of LY6E is significantly higher after radiotherapy, suggesting that LY6E is a potential effective molec- ular marker for accurate radiotherapy of gastric cancer.
作者
简国浩
孙海橦
杨婧怡
敖磊
汤在祥
JIAN Guo-hao;SUN Hai-tong;YANG Jing-yi(Department of epidemiology and healty statistics,School of public health,Suzhou University,Suzhou 215000,China)
出处
《吉林医学》
CAS
2018年第10期1813-1816,共4页
Jilin Medical Journal
基金
国家自然科学基金[项目编号:81773541]
苏州大学医学部学生课外科研项目[项目编号:81573253]
