摘要
目的以胰高血糖素样肽-1受体为靶点的^(68)Ga-exendin-4PET/CT是近年来新兴的诊断胰岛素瘤的新技术。由于^(68)Ga-exendin-4在肾脏异常浓聚,本研究旨在探明琥珀酰明胶注射液降低肾脏摄取^(68)Ga-exendin-4的有效性。方法本研究为随机对照研究,研究纳入≥18岁且肾功能正常的拟行^(68)Ga-exendin-4 PET/CT的患者,随机分为实验组及对照组。实验组经静脉滴注500mL琥珀酰明胶注射液,对照组滴注500mL 5%葡萄糖氯化钠注射液,滴注完毕后即刻经静脉注射^(68)Ga-exendin-4示踪剂,之后行PET/CT检查,并测量肾脏、胰岛素瘤病灶和正常胰腺组织的SUV。结果研究共入组29例患者,实验组及对照组分别为14例,1例因对琥珀酰明胶注射液过敏退出本研究。实验组及对照组的年龄、性别、体重、体质指数、肾功能、^(68)Ga-exendin-4的注射剂量、显像间隔时间差异均无统计学意义。实验组肾脏的平均SUV和最高SUV均显著低于对照组(P <0. 0001),琥珀酰明胶注射液预滴注可将肾脏的放射性摄取降低59%。实验组和对照组的胰岛素瘤病灶的平均SUV、最高SUV差异无统计学意义,但实验组的正常胰腺组织平均SUV显著高于对照组(P<0.0001)。结论琥珀酰明胶注射液能够安全、有效的降低人体肾脏对^(68)Ga-exendin-4的摄取。
Objective Glucagon-like peptide-l receptor imaging, using 68Ga-exendin-4, is recently established for detecting insulinomas. Owing to the highly radioactive enriched kidneys in 6SGa-exendin-4 PET/CT, we aimed to determine the effect of succinylated gelatin in reducing renal uptake of 68Ga-exendin-4. Methods In our randomized controlled study, patients presenting for 6SGa-exendin-4 PET/CT who were ≥18 years and with normal renal function were enrolled, and then randomized into the intervention group and the control group. Patients in intervention group underwent infusion of 500mL succinylated gelatin before injection of 6s Ga-exendin-4. The control group received 500mL 5 % glucose saline instead. PET/CT was then performed, and SUVs of the kidney, insulinoma, and normal pancreas were measured. Results A total of 29 patients were recruited. There were 14 patients in each group, and 1 patient was excluded in the study because of allergy to succinylated gelatin. The age, sex, body weight, BMI, renal function, injected 6SGa-exendin-4 activity, and interval between injection of the tracer and PET/CT scan were not significantly different between the groups. The average and maximum SUVs in the kidneys were significantly reduced in patients of intervention group compared with the control subjects （ P 〈 0. 0001 ）. The renal uptake could be decreased by 59% with succinylated gelatin pre-treatment. In insulinomas cases, the uptake was not significantly different between the intervention and control group. However, the average SUVs of normal pancreas in intervention group weresignificantly higher than that in the controls （P 〈 0. 0001 ）. Conclusion Renal uptake of 6SGa-exendin-4 can be effectively and safely reduced by pre-treatment with succinylated gelatin.
作者
罗亚平
潘青青
朱朝晖
李方
LUO Ya-ping;PAN Qing-qing;ZHU Zhao-hui;LI Fang(Department of Nuclear Medicine,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China;Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine,Beijing 100730,China)
出处
《标记免疫分析与临床》
CAS
2018年第9期1253-1258,共6页
Labeled Immunoassays and Clinical Medicine
基金
国家自然科学基金(编号:81501515)
