摘要
目的调查药源性剥脱性皮炎的发生特点及诊疗方法,为临床合理用药提供参考。方法计算机检索中国知网、万方数据库、PubMed、Embase电子数据库有关药物致剥脱性皮炎的不良反应文献并结合手工检索不良反应网站,检索时间为2000～2018年,查阅药物型剥脱性皮炎的病例报道。按照相关项目录入SPSS22.0对性别、年龄以及药物品种、类别、给药途径等用药情况进行统计分析。结果共查阅药物型剥脱性皮炎报道285篇,文献中包含病例320例,其中男性占60.30%,女性占38.13%,男性发病率高于女性,差异有统计学意义(P<0.05);年龄分布以成年人为主;其中有63.75%的患者存在药物过敏史或皮肤病史;大部分患者的症状能在1个月内得到控制或治愈。结论药物致剥脱性皮炎与性别有一定的关联性,且患者预先存在的皮肤病及其治疗可能是引起ED发生的主要原因。
Objective To investigate the occurrence characteristics and diagnosis and treatment methods of drug-induced exfoliativedermatitis,and provide reference for clinical rational drug use.Methods Computers were searched for the adverse reactions of drug-induced exfoliative dermatitis in China Knowledge Network,Wanfang Database,PubMed,and Embase electronic databases,andcombined with manual retrieval of adverse reaction sites.The search time was as 2000 to 2018,and the case report of drug -typeexfoliative dermatitis was reviewed.According to the relevant items,SPSS22.0 was used to analyze the sex,age,drug type,category,androute of administration.Results A total of 285 cases of drug-type exfoliative dermatitis were reported.There were 320 cases in theliterature,including 60.30% of males and 38.13% of females.The male incidence rate was higher than that of females,the differencewas statistically significant（ P〈0.05）;age distribution adults are the main;63.75% of them havea history of drug allergy or skin history;most patients can be controlled or cured within1 month.Conclusion Drug-induced exfoliative dermatitis hasa certain correlationwith gender,and pre-existing skin diseases and treatment may be the main cause of ED.
作者
季士亮
JI Shi-liang1,2(1.Clinical Pharmacy Room,Suzhou Science and Technology Town Hospital,Suzhou 215000,Jiangsu,China;2.Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215000,Jiangsu,Chin)
出处
《医学信息》
2018年第18期112-114,共3页
Journal of Medical Information
关键词
药物不良反应
剥脱性皮炎型药疹
药学监护
Adverse drug reaction
Exfoliative dermatitis eruption
Pharmaceutical monitoring
