摘要
目的探讨磷酸化信号转导及转录激活蛋白3(p-STAT3)在胃癌组织中的表达及其与病人预后的关系。方法选取我院2015年1月—2017年5月收治的胃癌病人98例,收集其术后胃癌组织(胃癌组)及其中40例病人的术后癌旁组织(癌旁组),采用免疫组化染色检测两组标本p-STAT3的蛋白表达,分析p-STAT3蛋白表达与病人临床病理特征及预后的关系。结果胃癌组织p-STAT3蛋白阳性表达率为72.45%,显著高于癌旁组织20.00%的阳性表达率,差异有统计学意义(χ~2=31.927,P<0.05)。胃癌组织中p-STAT3蛋白阳性表达率与肿瘤的临床分期、分化程度、浸润深度、淋巴结转移有关(χ~2=3.877～5.998,P<0.05),与病人的年龄、性别和肿瘤直径无关(P>0.05)。p-STAT3蛋白阳性表达胃癌病人的1、2年生存率与阴性表达病人比较差异无统计学意义(P>0.05);p-STAT3蛋白阴性表达胃癌病人的3年生存率为51.85%,显著高于阳性表达病人的26.76%(χ~2=5.998,P<0.05)。p-STAT3蛋白阴性表达病人生存时间显著长于阳性表达病人,差异具有统计学意义(Log Rank(Mantel-Cox)=10.115,P<0.05)。结论 p-STAT3蛋白在胃癌组织中高表达,与病人的不良预后关系密切。
Objective To investigate the expression of p-STAT3 in gastric carcinoma tissue and its association with patient prognosis. Methods A total of 98 patients with gastric carcinoma who were admitted to our hospital from January 2015 to May 2017 were enrolled. Postoperative gastric carcinoma tissue samples were collected from all patients （gastric carcinoma group）, and postoperative adjacent tissue samples were collected from 40 patients （adjacent group）. Immunohistochemical staining was used to measure the expression of p-STAT3 protein, and its association with clinicopathological features and prognosis was analyzed.Results The gastric carcinoma tissue group had a significantly higher expression rate of p-STAT3 protein than the adjacent tissue group （72.45% vs 20.00%; χ^2=31.927, P 〈0.05）. The expression rate of p-STAT3 protein in gastric carcinoma tissue was associated with clinical stage, degree of tumor differentiation, depth of infiltration, and lymph node metastasis （ χ^2=3.877-5.998, P 〈 0.05）, while it was not associated with age, sex, and tumor diameter （ P 〉0.05）. There were no significant differences in 1-and 2-year survival rates between the gastric carcinoma patients with positive expression of p-STAT3 and those with negative expression （ P 〉0.05）, while the patients with negative expression of p-STAT3 had a significantly higher 3-year survival rate than those with positive expression （51.85% vs 26.76%; χ^2=5.998, P 〈0.05）. The patients with negative expression of p-STAT3 had a significantly longer survival time than those with positive expression （Log-rank （Mantel-Cox）=10.115, P 〈0.05）. Conclusion P-STAT3 protein is highly expressed in gastric carcinoma tissues and is closely associated with the poor prognosis of patients.
作者
郭浚
曹玉刚
GUO Jun;CAO Yugang(Department of Hepatobiliary Surgery,Huangshi Central Hospital,Hubei East Health Group,Huangshi 435000,China)
出处
《青岛大学学报（医学版）》
CAS
2018年第5期540-543,共4页
Journal of Qingdao University(Medical Sciences)
基金
湖北省自然科学基金资助项目(2016FFB04310)
关键词
胃肿瘤
STAT3转录因子
预后
stomach neoplasms
STAT3 transcription factor
prognosis
