摘要
目的:通过文献分析了解我国绝经期取器前宫颈准备常用药物的用药方案和临床效果。方法:对CNKI和万方数据库中1978年—2017年的相关文献进行检索。结果:纳入207篇文献。宫颈准备的药物主要分为雌激素类、前列腺素类和替勃龙3类。文献数量排在前3位的药物是米索前列醇75篇,戊酸雌二醇51篇和尼尔雌醇38篇。尽管用药剂量和疗程不统一,但在有对照组的文献中,均显示有较明显的宫颈扩张作用和较高的顺利取出率。值得关注的是绝大多数文献研究设计不够严谨,样本量不充分,观察指标不统一、不完全,使所获得的结果欠可靠,仅能作为参考。结论:建议今后进行严格设计的多中心大样本的临床研究,为确定有效的药物宫颈准备方案提供高水平的证据。
This review aims to understand the medicine regimen and clinical effects of common medicine for cervical preparation before IUD removal of postmenopausal women in China. Multiple electronic databases which including CNKI and Wanfang Database was searched systematically. Reference lists of articles published in Chinese between 1978 and 2017 were searched and 207 articles were included. The medicines used for cervical preparation are divided into three categories： estrogens, prostaglandins and tibolone. The top three medicines mentioned in the literature were misoprostol, estradiol valerate and nilestriol, for the literature number of 75, 51 and 38. In control trails, although the dose and duration of treatment are different, effects of cervical dilatation are obvious, and the successful removal rates are high. It is noteworthy that most researches don’t design rigorous enough, the sample sizes are not sufficient, and the observation indicators are not uniform or incomplete, so that the results obtained are not reliable and can only be used as a reference. It is recommended that a rigorously designed multi center, large sample clinical study should be conducted in the future to provide high level of evidence for the identification of effective cervical drug preparation solution.
作者
赵新
李来宝
吴尚纯
ZHAO Xin;LI Laibao;WU Shangchun(Peking Union Medical College Graduate School,National Research Institute for Family Planning,Beijing,100081)
出处
《中国计划生育学杂志》
2018年第10期893-896,共4页
Chinese Journal of Family Planning
关键词
绝经期
取器
宫颈准备
Menopause
Removal of intrauterine devices
Medicine for cervical preparation
