摘要
目的研究分析枸橼酸咖啡因与氨茶碱在临床中治疗早产儿原发性呼吸暂停的效果以及安全情况。方法选择于2016年5月至2017年6月到我院接受治疗的114例早产儿原发性呼吸暂停患儿,并进行回顾性分析。根据治疗方式将其分为对照组(n=57)与观察组(n=57)。对照组行氨茶碱治疗,观察组行枸橼酸咖啡因与氨茶碱联合治疗,比较两组患儿治疗后的临床疗效以及安全性情况。结果经过不同方式治疗后,观察组、血浆β-EP、呼吸暂停终止时间以及用氧时间均显著优于对照组,差异具有统计学意义(P<0.05);呼吸暂停发作的持续时间、发作次数以及症状消除时间均显著优于对照组,差异具有统计学意义(P<0.05);HR、PaO_2、SpO_2指标水平显著优于对照组,差异具有统计学意义(P<0.05)。结论对于原发性呼吸暂停早产儿在临床中选择枸橼酸咖啡因以及氨茶碱进行联合治疗,可改善其呼吸暂停症状、血浆β-EP水平、时间指标等,安全性较高,可有效改善预后,在临床中具有实用价值以及推广价值。
Objective To study the clinical efficacy and safety of caffeine and aminophylline in the treatment of primary apnea in preterm infants. Methods A total of 114 children with primary apnea who were treated in our hospital from May 2016 to June 2017 were selected and retrospectively analyzed. According to the treatment, they were divided into control group（n=57） and observation group（n=57）. The control group was treated with aminophylline. The observation group was treated with caffeine citrate and aminophylline. The clinical efficacy and safety of the two groups were compared. Results After treatment with different methods, the observation group, plasma β-EP, duration of apnea and oxygen use time were significantly better than the control group. The difference was statistically significant（P〈 0.05）; Duration of onset of apnea attack, seizure The number of times and the time of symptom elimination were significantly better than those of the control group（P〈 0.05）. The levels of HR, PaO2, and SpO2 were significantly higher than those of the control group. The difference was statistically significant（P〈 0.05）. Conclusion The combination of caffeine citrate and aminophylline for the treatment of primary apnea in preterm infants can improve their apnea symptoms, plasma β-EP levels, time indexes, etc. Can effectively improve the prognosis, has practical value and promotion value in clinical practice.
作者
彭光晶
雷会艳
PENG Guang-jing;LEI Hui-yan(The First People＇s Hospital of Urumqi,Urumqi,Xinjiang 83000)
出处
《智慧健康》
2018年第23期41-43,共3页
Smart Healthcare
