摘要
目的探讨西妥昔单抗联合铂类药物灌注治疗胃癌恶性腹水患者的疗效。方法选取2013年1月至2014年10月间河北大学附属医院收治的66例胃癌合并恶性腹水患者作为研究对象,依据入院时间依次纳入观察组和对照组,每组33例。观察组患者予以西妥昔单抗联合铂类药物治疗,对照组患者予以铂类药物灌注治疗。比较两组患者的治疗效果、生活质量(Karnofsky评分)、血清内皮生长因子(VEGF)和循环内皮细胞(CECs)含量以及不良反应发生情况。结果观察组患者治疗后的有效率和疾病控制率均明显优于对照组,差异均有统计学意义(均P<0.05)。治疗后,观察组患者生活质量评分优于对照组患者,差异有统计学意义(P<0.05)。治疗后,两组患者血清VEGF和CECs含量降低,且观察组血清VEGF和CECs水平低于对照组,差异均有统计学意义(均P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论西妥昔单抗联合铂类药物灌注治疗胃癌恶性腹水患者具有较好治疗效果,同时可保护内皮功能,提高患者生活质量,值得广泛应用于临床。
Objective To explore the efficacy of cetuximab combined with platinum drug infusion for malignant ascites caused by gastric cancer. Methods From January 2013 to October 2014,66 patients with gastric cancer complicated with malignant ascites were selected as the study group. According to the time of sequence,they were included into an observation group,and a control group with 33 patients in each group. The observation group received cetuximab combined with platinum drug infusion therapy,and the control group received platinum drugs infusion. The treatment efficacy,quality of life（ Karnofsky scores）,the serum endothelial growth factor（ VEGF） and circulating endothelial cells（ CECs） levels and the incidence of adverse reactions were compared between the two groups. Results The efficiency and disease control rate were significantly better in the observation group in the control group（ all P〈0. 05）. The quality of life in the observation group was better than in the control group after the treatment（ P〈0. 05）. Serum VEGF and CECs levels decreased in the two groups after the treatment（ all P〈0. 05）. What＇ more the serum VEGF and CECs levels were lower in the observation group than in the control group（ all P〈0. 05）There was no significant difference in the incidence of adverse reactions between the two groups（ P〈0. 05）. Conclusion Cetuximab combined with platinum drug perfusion has good therapeutic efficacy in the treatment of malignant ascites due to gastric cancer. It can protect endothelial function and improve quality of life in patients with gastric cancer complicated with malignant ascites. It is worthy of wide application in clinics.
作者
杨阳
杨晴
贾友超
刘斌
杨华
任莉莉
臧爱民
YANG Yang;YANG Qing;JIA You-chao;UU Bin;}rANG Hua;REN Li-li;ZANG Ai-min(Department of Oncology,Hebei Key Laboratory Project of Tumor Radiotherapy and Chemotherapy Mechanisms and Regulation,Hebei University Affiliated Hospital,Baoding 071000,China)
出处
《中国肿瘤临床与康复》
2018年第10期1185-1188,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
西妥昔单抗
铂类
胃肿瘤
恶性腹水
Cetuximab
Platinum
Gastric neoplasms
Malignant ascites
