摘要
目的研究分析不育症患者染色体核型与生殖激素水平的变化。方法对348例无精或少弱精子症患者抽取外周血进行生殖激素水平和染色体核型检查。结果无精子症患者的FSH和LH水平明显高于正常对照组,差异显著(P<0.05),而T水平低于正常对照组,差异显著(P<0.05)。PRL及E2无明显差异。而少弱精子患者的生殖激素水平与正常对照组差异无统计学意义。348例无精子症患者中检出染色体异常93例,检出率为26.72%。其中性染色体异常61例,占总染色体异常的65.59%;常染色体异常32例,占34.41%。结论无精子症与染色体异常和生殖激素水平密切相关。
Objective：To study the male infertile patients with peripheral blood chromosome karyotype analysis and reproductive hormone level. Methods：In 348 cases of male infertile patients with peripheral blood karyotype analysis and detection level of serum reproductive hormones. Results：FSH and LH levels of no sperm group was obviously higher than that of healthy control group,significant difference（P〈0.05）. and T level of no sperm group was obviously lower than that of healthy controls,the significant difference（P〈0.05）. PRL and E2 were no obvious difference. 348 cases detected in patients with azoospermatism chromosome aberrations in 93 cases,accounting for 26.72%. Among them,61 cases of sex chromosome abnormality,accounts for 65.59%,abnormal autosomal（32 cases）,accounting for 34.41%. Conclusion：No sperm and abnormal chromosome karyotype and reproductive hormone level has a close relationship.
作者
陈跃瑜
朱琳
梁晓云
梁建恩
林延润
黄倩婷
杨发达
CHEN Yue-yu;ZHU Lin;LIANG Xiao-yun;LIANG Jian-en;LIN Yan-run;HUANG Qian-ting;YANG Fa-da(Prenatal Diagnosis Center Affiliated Nanhai Maternity and Children＇s Health Care Hospital of Guangdong,Foshan,52820)
出处
《中国优生与遗传杂志》
2018年第9期46-47,45,共3页
Chinese Journal of Birth Health & Heredity
关键词
不育症
染色体
生殖激素
Infertility
Chromosome
Reproductive hormones
