摘要
目的观察分析二甲双胍(MET)联合罗格列酮(RSG)治疗新诊断2型糖尿病(T2MD)患者对胰岛β细胞功能的影响。方法收集我院2016年6月～2017年5月诊治的156例新诊断T2DM患者,随机分为对照组(MET组)78例和治疗组(MET联合RSG组)78例,分别记录空腹血糖(FPG)、糖化血红蛋白(HbA1C)、空腹胰岛素(FINS)、血脂等,连续治疗32周观察指标变化。结果 (1)治疗组临床总有效率明显优于对照组(P <0.05),两组患者在用药期间无严重不良反应发生。(2)两组治疗后糖代谢和胰岛β细胞功能均获改善(P <0.05),且治疗组比对照组改善更明显(P <0.05)。结论 MET联合RSG治疗新诊断T2DM临床疗效显著,用药安全;能显著改善糖代谢异常并改善胰岛β细胞功能。
Objective To investigate the effect of metformin（MET） and rosiglitazone（RSG） combination therapy on islet beta cell function in newly diagnosed type 2 diabetes（T2DM） patients. Methods One hundred and fifty-six newly diagnosed T2DM patients who treated in our hospital from June 2016 to May 2017 were selected and randomly divided into observation group（MET group） and control group（RSG combined MET group）, 78 cases in each group. All them were treated for 32 weeks. The fasting blood glucose（FPG）, hemoglobin A1C（HbA1C）, fasting plasma insulin level（FINS） and lipid profile in two groups were analyzed. Results （1）In observation group, the clinical effect was 89.74% which was significantly better than those in control group（76.93%）, P 〈 0.05. There was no severe adverse reaction during treatment course in two groups. （2）After treatment, the glucose metabolism and islet beta cell function were ameliorated in both two groups（P 〈 0.05）. In addition, the results of the observation group were much better than those of control group（P 〈 0.05）. Conclusion MET combines RSG therapy can significantly increase the clinical effect in newly diagnosed T2DM patients. Besides, there was no severe adverse reaction during treatment course. This treatment protocol is safe and can ameliorate glucose metabolism and improve islet beta cell function.
作者
吕媛媛
马慧璇
LV Yuanyuan; MA Huixuan;(Department of Endocrinology, Guangzhou First People＇ s Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou 510180, China)
出处
《中国医药科学》
2018年第18期35-37,45,共4页
China Medicine And Pharmacy
关键词
2型糖尿病
二甲双胍
罗格列酮
胰岛功能
疗效观察
Type 2 diabetes mellitus
Metformin
Rosiglitazone
Pancreatic islet cell function
Observation of curative effeetn
