摘要
目的 探讨消化系统恶性肿瘤疾病中血清甲胎蛋白（AFP）、高尔基体蛋白73（GP73）、糖链抗原125（CA125）联合检测的诊断价值.方法 本院于2015年3月至2017年3月期间收治的100例消化系统恶性肿瘤患者为肿瘤组.另选取本院同期收治的消化道系统良性疾病者98例为良性组,此外选取本院同期进行体检的健康者100例作为对照组,测定血清AFP、GP73及CA125水平,分析血清AFP、GP73及CA125联合检测诊断消化系统恶性肿瘤的ROC曲线下面积、敏感性、特异性及准确度.结果 恶性肿瘤组血清AFP、GP73、CA125水平分别为（144.91±30.54） mg/L、（92.87±13.25） mg/ml、（166.05±30.29） U/ml显著高于良性组和对照组,差异有统计学意义（P＜0.05）;AFP、GP73及CA125单独诊断消化系统恶性肿瘤的ROC曲线下面积分别为0.701,0.725,0.669,而GP73＋CA125、GP73＋AFP及GP73＋CA125＋AFP诊断消化系统恶性肿瘤的ROC曲线面积为0.752、0.726和0.921,GP73＋CA125＋AFP诊断的ROC曲线下面积显著高于GP73＋CA125、GP73＋AFP,差异有统计学意义（P＜0.05）.结论 血清AFP、GP73及CA125联合检测可提高消化系统恶性肿瘤疾病早期诊断的特异性及准确性,对于消化系统恶性肿瘤疾病早期的预测具有重要价值.
Objective To explore the value of the combination of serum levels of AFP,GP73,and CA125 in diagnosis of malignant tumors of digestive system.Methods 100 patients with malignant tumors of digestive system treated at our hospital from March,2015 to March,2017 were set as a malignancy group,98 patients with benign tumors a benign group,and 100 healthy objects taking physical examination a control group.The serum levels ofAFP,GP73,and CA125 were detected.The area under curve （AUC） of Receiver Operating Characteristic（ROC）,sensitivity,specificity,and accuracy of the combination of AFP,GP73,and CA 125 in the diagnosis of malignant tumors of digestive system were analyzed.Results The levels of AFP,GP73,and CA 125 were （144.91±30.54） mg/L,（92.87±13.25） mg/ml,and （166.05±30.29） U/ml in the malignancy group,which were significantly higher than those in the benign group and the control group （P〈0.05）.The AUC of AFP,GP73,and CA125 in the diagnosis of malignant tumors were 0.701,0.725,and 0.669,（P〈0.05）,respectively.The area under the ROC curve of the combinations ofGP73＋CA125,GP73＋AFP,and GP73＋CA125＋AFP were 0.752,0.726,and 0.921,respectively.Conclusion Combination of serum levels ofAFP,GP73,and CA125 in the diagnosis of malignant tumors of digestive system can improve the specificity and accuracy of early diagnosis and has early predictive value.
作者
聂淼
綦淑杰
Nie Miao;Qi Shujie(Department of Internal Medicine,Jiaozhou Municipal People＇s Hospital,Jiaozhou 266300,China)
出处
《国际医药卫生导报》
2018年第20期3169-3173,共5页
International Medicine and Health Guidance News
