摘要
目的探讨榄香烯注射液联合化疗对增强中晚期胃癌化疗效果的作用。方法回顾性分析,将2015年6月至2017年6月在上海市浦南医院接受治疗的60例中晚期胃癌患者作为研究对象进行回顾性分析,根据治疗方法将患者分为两组:对照组患者30例,采取单纯FOLFOX6化疗治疗;观察组患者30例,在对照组基础上加用榄香烯注射液治疗。比较两组患者治疗前后的免疫功能指标、临床治疗效果以及不良反应发生情况。结果观察组患者治疗后的CD4^+、CD4^+/CD8^+免疫功能指标分别为(30. 67±3. 42)%、(1. 14±0. 43),显著优于对照组,差异具有统计学意义(P <0. 05);观察组治疗后有22例患者显示有效,占73. 3%,显著高于对照组的50. 0%,差异具有统计学意义(P <0. 05);观察组患者治疗后不良反应发生率为10. 0%(3/30),与对照组的40. 0%(12/30)比较,差异具有统计学意义(P <0. 05)。结论榄香烯注射液联合化疗治疗中晚期胃癌能够促进患者免疫功能改善,减少不良反应,效果显著,值得推广应用。
Objective To explore the effect of Elemene injection combined with chemotherapy in treatment of advanced gastric cancer.Methods 60 patients with advanced gastric cancer treated in this hospital during June 2015 to June 2017 were divided into two groups ： 30 cases in control group and 30 patients in observation group. Patients in control group were treated with chemotherapy alone, and 30 patients in observation group were treated with Elelnene injection on the basis of treatment in control group. The inunune function, clinical efficacy and adverse reactions of patients in these two groups were compared before and after treatment. Results The inunune function indexes of CD4^＋ and CD4^＋/CD8^＋ in observation group were （30.67 ± 3.42）% and （1.14 ± 0.43 ） respectively, which were significantly better than those in control group. The difference was statistically significant （ P 〈0.05） , and 22 patients in observation group were effective, accounting for 73.3% , they were significantly higher than those of control group. The difference was statistically significant （ P 〈 0.05 ）. The incidence of adverse reactions in observation group was 10% （3/30） after treatment, and the difference was statistically significant （ P 〈 0.05 ） in comparison with that of control group （12/30）. Conclusion The combined chemotherapy with Ehnenei injection in treatment of mid and late stage gastric cancer can promote the improvement of immune function and reduce the adverse reactions, and the efficacy is remarkable, hence It is worthy to be popularized.
作者
安贞兰
魏玮
姚新明
赵玲
智慧
AN Zhen-lan;WEI-wei;YAO Xin-ming(Department of Oncology,Shanghai Pu Nan Hospital,Shanghai 200125,China)
出处
《临床和实验医学杂志》
2018年第22期2422-2424,共3页
Journal of Clinical and Experimental Medicine
关键词
中晚期胃癌
揽香烯注射液
化疗
免疫功能
Mid and advanced gastric cancer
Elelnene Injection
Chemotherapy
hnlnunity
