摘要
目的观察临床应用早期康复训练联合骨肽注射液对桡骨近腕关节处骨折恢复时间及腕关节功能的影响。方法采用前瞻性研究方法,将2014年8月至2017年6月在四川大学华西医院诊治的94例桡骨近腕关节处骨折患者按照随机平行分组法分为对照组和观察组,每组各47例。两组患者均在常规固定治疗后进行早期康复训练治疗,观察组患者同时给予骨肽注射液联合治疗,对照组未配合药物治疗,对比分析两组患者的腕关节功能恢复情况、骨折恢复情况、治疗前及治疗2周后红细胞相关指标和骨代谢相关指标变化。结果治疗前两组患者腕关节功能背伸度、掌屈度、桡角度、旋前度以及旋后度比较差异无统计学意义(P> 0. 05),治疗后上述检测指标均有明显改善(P <0. 05),观察组改善程度明显高于对照组(P <0. 05)。治疗后对照组患者疼痛消失时间、瘀斑消失时间、临床愈合时间和骨性愈合时间均明显长于观察组[(22. 51±6. 24) d vs.(18. 46±5. 40) d,(15. 44±3. 62) d vs.(12. 96±2. 34) d,(81. 39±6. 39) d vs.(62. 45±4. 21) d,(116. 62±7. 25) d vs.(99. 54±3. 49) d); P <0. 05];治疗后两组患者红细胞积聚指数(EAI)、红细胞电泳指数(EEI)水平均明显下降(P <0. 05),红细胞免疫促进因子(FEER)和直向肿瘤红细胞花环率(DTER)则明显升高(P <0. 05),观察组上述指标变化幅度均明显高于对照组(P <0. 05);治疗后两组患者血清碱性磷酸酶(ALP)、酸性磷酸酶(ACP)、前胶原羧基端肽(PICP)、骨钙素(BGP)水平均明显升高(P <0. 05),观察组上述指标升高幅度明显高于对照组(P <0. 05)。结论对桡骨近腕关节处骨折患者进行早期康复训练的同时联合应用骨肽注射液治疗可明显缩短恢复时间,促进腕关节功能改善,值得在临床推广应用。
Objective To observe the effect of early training combined with osteopeptin injection on the recovery time and function of wrist fracture at the proximal wrist of radius. Methods A prospective study was conducted in 94 patients with fractures of the proximal wrist of radius treated in West China Hospital of Sichuan University from August 2014 to June 2017. Two groups of patients were treated with early rehabilitation training after routine fixation. The observation group was treated with osteopeptide injection, while the control group was not treated with medicine. The wrist function recovery, fracture recovery, red blood cell related indexes and related indicators changing of bone metabolism in the two groups were compared and analyzed. Results Before treatment, there was no statistically significant difference in the test indexes of wrist joint function between the two groups （ P 〉 0.05）. After treatment, all the test indexes were significantly improved （ P 〈 0.05 ） , and the improvement degree of the observation group was significantly higher than that of the control group （ P 〈 0.05 ）. The time of pain disappeared, the time of ecchymosis disappeared, the time of clinical healing and the time of bone healing were significantly longer than the observation group [ （ 22.51 ± 6.24 ） d vs. （18.46±5.40） d, （15.44±3.62）dvs. （12.96±2.34） d, （81.39±6.39） dvs. （62.45±4.21） d, （116.62±7.25） dvs. （99.54 ± 3.49） d） , P 〈 0.05 ]. After treatment, the erythrocyte accumulation index （EAI） ancl erythrocyte electrophoresis index （EEl） of the two groups were significantly decreased （ P 〈 0.05 ） , while the erythrocyte inunune promoter factor （FEER） and direct tumor erythrocyte garland rate （DTER） were significantly increased （ P 〈 0.05）. After treatment, serum ALP, ACP, procollagen carboxylated peptide （PICP） and osteocalcin （BGP） levels of the two groups were significantly increased （ P 〈 0.05）. Conclusion The combined treatment of bone peptide injection can significantly shorten the recovery time and improve the function of the wrist.
作者
俞泳
张蕾
王立生
何成奇
YU Yong;ZHANG Lei;WANG Li-sheng(Department of Rehabilitation Medicine,West China Hospital,Sichuan University,Chengdu Sichuan 610041,China)
出处
《临床和实验医学杂志》
2018年第22期2433-2436,共4页
Journal of Clinical and Experimental Medicine
基金
四川省卫生厅科研项目(编号:16PJ314)
关键词
桡骨近腕关节处骨折
骨肽注射液
早期康复训练
恢复时间
腕关节功能
Fracture of the proximal wrist of the radius
Bone peptide injection
Early training
Recovery time
Wrist joint function
