摘要
目的:观察脑卒中后焦虑抑郁伴有失眠症状之患者抑郁症状、焦虑症状以及失眠的严重程度并进行治疗评估,以及患者应用艾司西酞普兰进行治疗的临床效果及服药后不良反应的发生情况。方法:选取2016年1月至2018年1月福建医科大学附属协和医院平潭分院收治的脑卒中后焦虑抑郁伴失眠症状患者100例,随机分为观察组和对照组,每组50例。观察组患者应用予艾司西酞普兰进行治疗,对照组应用氯丙咪嗪进行治疗。在患者服药半年后,运用汉密顿抑郁评估量表(HAMD)、汉密顿焦虑评估量表(HAMA)、匹兹堡睡眠质量指数(PSQI),针对患者的抑郁、焦虑症状以及失眠的严重程度,并统计2组患者服药过程中发生不良反应的记录与治疗效果进行比较。结果:治疗后观察组患者汉密顿抑郁评分(HAMD)、汉密顿焦虑评分(HAMA)、匹兹堡睡眠质量指数(PSQI)明显较对照组低,差异有统计学意义(P <0. 05)。根据2组部分患者用药后均出现的口干舌燥、多汗、困倦乏力、失眠等不良反应作为观察指标,发现观察组患者出现不良反应的概率较对照组低,但数据差异无统计学意义(P> 0. 05)。结论:确诊脑卒中后焦虑抑郁伴有失眠症状之患者应用艾司西酞普兰进行治疗具有良好的改善或控制效果,且不良反应较应用氯丙咪嗪进行治疗的患者低。
Objective： To observe the depression symptoms, anxiely symptoms and the severity of insonmia in pa-tients with post-stroke anxiety and depression accompanied by insonmia, and to evaluate the treatment And the clinical effect and adverse reaction of patients treated with estalopram Methods： From January2016 to January 2018, 100 pa-tients with post-stroke anxiety and depression associated with insonmia were selected and randomly divided into observation group and control group with 50 eases in each group. Patients in the observation group were treated with estalopram and the control group were treated with chlorimipramine. After half a year of medication, the Hamilton Depression Assessment scale （HAMD）, the Hamilton anxiety Assessment scale （HAMA）, the Pittsburgh Sleep quality Index （PSQI）, was used to assess the severity of depression, anxiety and insomnia. The adverse reactions of the two groups were recorded and com-pared with the results of treatment, Results： After treatment, Hamilton depression score, Hamilton anxiety score and Pittsburgh sleep quality index in the observation group were significantly lower than those in the control group （P 〈 0. 05 ） . According to the adverse reactions such as dryness of the mouth, sweating, fatigue, insomnia and so on, the probability of adverse reactions in the observation group was lower than that in the control group. But there was no significant difference in data （P 〉 0. 05 ）. Conclusion： The patients with anxiety and depression associated with insomnia after stroke had good effect of improving or controlling, and the adverse reaction was lower than that of patients treated with chlorimipra-mine.
作者
林巧芳
Lin Qiaofang(Department of Neurology,Pingtan Braneh,Union Hospital,Fujian Medical University,Pingtan,35040)
出处
《世界睡眠医学杂志》
2018年第10期1175-1177,共3页
World Journal of Sleep Medicine
