摘要
目的研究转移性淋巴结比率(MLNR)在胆囊癌患者中的预后意义及建立基于MLNR的淋巴结转移胆囊癌预后模型。方法收集SEER数据库2010-2014年间接受手术切除的淋巴结转移的胆囊癌患者374例,采用Kaplan-Meier法分析MLNR对患者预后的影响,采用Cox多因素分析判断MLNR是否为独立的预后因素并建立列线图预测模型。结果 Kaplan-Meier分析示高MLNR(MLNR2)较低MLNR(MLNR1)预后差,差异有统计学意义(P=0.006);Cox多因素分析表明,MLNR是淋巴结转移胆囊癌患者的独立预后因素(P=0.039)。结论 MLNR是淋巴结转移胆囊癌患者独立预后因素,基于MLNR的预后模型有望更准确地为淋巴结转移的胆囊癌患者指导治疗、评估疗效及判断预后。
Objective To investigate the prognostic significance of metastatic lymph nodes ratio （MLNR） in patients withgallbladder cancer and to establish a prognostic model based on MLNR. Methods Data of 374 patients with lymph nodemetastatic gallbladder cancer undergoing surgical resection from 2010 to 2014 were collected from the SEER database. Theeffect of MLNR on prognosis was analyzed by Kaplan-Meier method. Cox multivariate survival analysis was used to estimatewhether MLNR was an independent prognostic factor and create a nomogramprediction model. Results Kaplan-Meier analysisshowed a poor prognosis in patients with high MLNR compared to those with low MLNR （P=0.006）. COX multivariate analysisshowed that MLNR was an independent prognostic indicator for patients with lymph node metastatic gallbladder carcinoma（P=0.039）. Conclusion MLNR is an independent prognostic factor for patients with lymph node metastatic gallbladder cancer.The prognostic model based on MLNR is expected to guide treatment, evaluate efficacy and judge prognosis more accurately forthe patients with lymph node metastatic gallbladder cancer.
作者
张怡
钱萍
ZHANG Yi;QIAN Ping(Department of Pathology,Jiaxing Traditional Chinese Medicine Hospital,Jiaxing 314000,China)
出处
《浙江医学》
CAS
2018年第20期2216-2219,共4页
Zhejiang Medical Journal
关键词
转移性淋巴结比率
胆囊癌
预后
列线图
Metastatic lymph node ratio；Gallbladder cancer；Prognosis；Nomogram
