摘要
目的分析妊娠期肝内胆汁淤积症(ICP)采用血清总胆汁酸(TBA)检测的临床价值。方法方便选取2016年1月—2017年12月在该院就诊的118例ICP患者作为实验组,同时选取同期在该院产检的60名健康孕妇作为对照组,对比两组孕妇TBA水平,并分析不同水平TBA孕妇分娩方式、产后出血率、新生儿窒息率。结果实验组孕妇TBA水平(41.31±3.61)μmol/L显著高于对照组(8.91±2.01)μmol/L(t=20.481,P<0.05)。实验组ICP轻度孕妇剖宫产率(32.56%)、产后出血率(4.56%)、新生儿窒息率(2.32%)和ICP中度孕妇32.43%、5.41%、2.70%对比差异无统计学意义(P>0.05),ICP重度孕妇剖宫产率(50.00%)、产后出血率(10.53%)、新生儿窒息率(10.53%)高于ICP轻度和中度孕妇,且高于对照组20.00%、3.30%、1.67%,差异有统计学意义(P<0.05)。结论定期检测孕妇TBA水平有利于早期发现ICP,且不同TBA水平可诊断ICP严重程度,及早采取有效的治疗措施,改善母婴结局。
Objective This paper tries to analyze the clinical value of detection of intrahepatic cholestasis of pregnancy （ICP） by serum total bile acid （TBA）. Methods A total of 118 patients with ICP who were admitted to the hospital from January 2016 to December 2017 were convenient enrolled as the experimental group. 60 healthy pregnant women who were in the hospital during the same period were selected as the control group. The TBA levels of the two groups were compared and analyzed. The TBA pregnant women delivery mode, postpartum bleeding rate, neonatal asphyxia rate were observed. Results The TBA level （41.31±3.61）μmol/L in the experimental group was significantly higher than that in the control group （8.91±2.01）μmol/L（t=20.481,P〈0.05）. In the experimental group, the cesarean section rate （32.56%）, postpartum hemorrhage rate （4.56%）, neonatal asphyxia rate （2.32%） and ICP moderate pregnant women 32.43%, 5.41%, 2.70% of the differences were not statistically significant（P〉0.05）, ICP cesarean section rate （50.00%）, postpartum hemorrhage rate （10.53%）, neonatal asphyxia rate （10.53%） were higher than ICP mild and moderate pregnant women, and higher than the control group 20.00%, 3.30%, and 1.67%, with statistical significance（P〈0.05）. Conclusion Regular detection of TBA levels in pregnant women is conducive to early detection of ICP, and different TBA levels can diagnose the severity of ICP, and take effective treatment measures early to improve maternal and infant outcomes.
作者
谢丽华
XIE Li-hua(Department of Obstetrics,Nanjing Gaochun People＇s Hospital,Nanjing,Jiangsu Province,211300 China)
出处
《中外医疗》
2018年第27期56-58,共3页
China & Foreign Medical Treatment
关键词
妊娠期肝内胆汁淤积症
血清总胆汁酸
临床检测
应用价值
Intrahepafic cholestasis of pregnancy
Serum total bile acid
Clinical dejection
Application value
