摘要
目的分析拉莫三嗪添加-替换治疗丙戊酸治疗无效的癫痫患者的临床疗效。方法将该院2015年5—9月的100例丙戌酸治疗无效的癫痫患者作为该次研究对象,随机分成对照组50例仅给予丙戌酸治疗,观察组50例则采取拉莫三嗪添加-替换治疗,对两组的临床治疗效果进行对比分析。结果观察组、对照组的临床治疗总有效率分别为96.0%(48/50)、80.0%(40/50),两者比较差异有统计学意义(χ~2=6.061,P<0.05)。结论为丙戌酸治疗无效的癫痫患者提供拉莫三嗪添加-替换治疗,能让患者的不良反应减少,有效提高患者治愈率,减少患者的住院时间,有效减少患者的死亡率,让临床疗效显著提高,值得临床推广。
Objective To analyze the clinical curative effect of lamotrigine addition replacement therapy of invalid epilepsy patients after the valproic acid therapy. Methods 100 cases of invalid epilepsy patients after the valproic acid therapy admitted and treated in our hospital from May to September 2015 were selected and randomly divided into two groups with 50 cases in each, the control group were treated with valproic acid, while the observation group used the lamotrigine addition- replacement therapy, and the clinical effect was compared and analyzed. Results The total clini- cal effective rates in the observation group and in the control group were respectively 96.0% （48/50）, 80.0% （40/50）, and the difference between the two groups was statistically significant （χ2=6.061, P〈0.05）. Conclusion The lamotrigine addition replacement therapy of invalid epilepsy patients after the valproic acid therapy can reduce the adverse reac tions, effectively improve the cure rate, reduce the length of stay, effectively reduce the death rate and obviously im prove the clinical curative effect, and it is worth clinical promotion.
作者
孙雪
SUN Xue(Department of Neurology,Luozhuang Central Hospital,Linyi,Shandong Province,276017 China)
出处
《系统医学》
2018年第18期75-77,共3页
Systems Medicine
关键词
癫痫患者
丙戌酸
拉莫三嗪添加-替换
临床疗效
Epilepsy patient
Valproic acid
Lamotrigine addition- replacement
Clinical curative effect
