摘要
目的:探讨盐酸氨溴索联合常规化疗治疗肺结核的临床疗效及护理措施。方法:选取2016年1月至2017年6月武汉大学人民医院潜江医院收治的肺结核患者98例,根据抽选顺序进行单双号分组,单号为观察组,双号为对照组,每组49例。对照组患者给予常规化疗,观察组患者在对照组的基础上加用盐酸氨溴索治疗,两组患者均给予针对性的护理。观察两组患者的临床疗效、咳嗽和喘息消失时间、实验室检查情况及不良反应发生情况。结果:观察组患者的总有效率为97.96%(48/49),明显高于对照组的79.59%(39/49),差异有统计学意义(P<0.05)。观察组患者平均咳嗽、喘息消失时间分别为(4.33±1.91)、(6.25±1.47)d,明显短于对照组的(6.78±1.84)、(8.49±1.52)d,差异均有统计学意义(P<0.05)。两组患者实验室检查结果的差异无统计学意义(P>0.05)。观察组、对照组患者不良反应发生率分别为4.08%(2/49)、2.04%(1/49),差异无统计学意义(P>0.05)。结论:盐酸氨溴索联合常规化疗治疗肺结核的疗效显著,可加快临床症状消失,且不良反应少。
OBJECTIVE： To probe into the clinical efficacy of ambroxol hydrochloride combined with conventional chemotherapy intervention in treatment of pulmonary tuberculosis. METHODS： 98 patients with pulmonary tuberculosis admitted into Qianjiang Hospital of People＇s Hospital Affiliated to Wuhan University from Jan. 2016 to Jun. 2017 were extracted to be divided into observation group and control group via the selection order,with 49 cases in each. The control group was given conventional treatment, while the observation group additionally received ambroxol hydrochloride based on the control group,and two groups were given targeted care. The clinical efficacy,disappearance time of cough and wheezing,laboratory inspection and incidence of adverse drug reactions of two groups were observed. RESULTS： The total effective rate of observation group was 97. 96%（ 48/49）,significantly higher than that of control group（ 79. 59%,39/49）,with statistically significant difference（ P〈0. 05）. The average disappearance time of cough and wheezing of observation group were respectively（ 4. 33 ± 1. 91） and（ 6. 25 ± 1. 47） d,significantly shorter than that of control group [（ 6. 78 ± 1. 84） and（ 8. 49 ± 1. 52） d],with statistically significant difference（ P〈0. 05）. There was no significant difference in laboratory test results between the two groups（ P〈0. 05）. The incidence of adverse drug reactions of observation group and control group were respectively 4. 08%（ 2/49） and 2. 04%（ 1/49）,the difference was not statistically significant（ P〈0. 05）. CONCLUSIONS： The efficacy of ambroxol hydrochloride combined with conventional chemotherapy in treatment of pulmonary tuberculosis is significant,which can accelerate the disappearance of clinical symptoms with fewer adverse drug reactions.
作者
吕桂芝
彭浩
LYU Guizhi;PENG Hao(Dept.of Infectious Disease,Qianjiang Hospital of People＇s Hospital Affiliated to Wuhan University,Hubei Qianjiang 433100,China)
出处
《中国医院用药评价与分析》
2018年第8期1058-1059,1062,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
肺结核
盐酸氨溴索
临床疗效
护理
Pulmonary tuberculosis
Ambroxol hydrochloride
Clinical efficacy
Nursing
