摘要
目的探讨半乳糖凝集素-1(galectin-1)和血管内皮生长因子(VEGF)在宫颈癌中的表达及其与临床特征的关系。方法选取宫颈鳞状细胞癌患者石蜡标本80例,宫颈上皮内瘤变患者的宫颈活检组织石蜡标本30例和正常宫颈上皮组织石蜡标本30例,通过免疫组织化学法检测galectin-1和VEGF的表达,对galectin-1和VEGF在宫颈鳞癌中的表达和与临床特征的关系进行统计学分析。结果 galectin-1、VEGF在宫颈鳞癌组织中的阳性表达率均高于宫颈上皮内瘤变组织及正常宫颈上皮组织,差异均有统计学意义(P﹤0.05)。galectin-1的阳性表达与FIGO分期有关(P﹤0.05),而与年龄、大体类型、分化程度及淋巴结转移无关(P﹥0.05)。VEGF的阳性表达与分化程度、FIGO分期和淋巴结转移有关(P﹤0.05),而与年龄、大体类型无关(P﹥0.05)。Spearman相关分析结果显示VEGF阳性表达与galectin-1阳性表达呈显著正相关(r=0.949,P=0.004)。结论 galectin-1和VEGF在宫颈鳞癌中的表达与肿瘤恶性程度、转移有关,可为临床治疗提供新的靶点。
Objective To explore the expression of galactose agglutinin-1（galectin-1） and vascular endothelial growth factor（VEGF）in cervical cancer and its relationship with clinical features. Method The paraffin embedded specimens from 80 cases of cervical squamous cell carcinoma, 30 cases of endothelial neoplasia and another 30 cases of normal cervical epithelium were collected. Expression of galectin-1 and VEGF were detected by immunohistochemistry. The expression of galectin-1 and VEGF in cervical squamous cell carcinoma and their relationship with clinical features were statistically analyzed. Result The positive expression rates of galectin-1 and VEGF in cervical squamous cell carcinoma were higher than those in the cervical intraepithelial neoplasia and normal cervical epithelium, with statistically significant differences observed（P〈0.05）. Positive expression of galectin-1 was associated with FIGO staging（P〈0.05）, rather than with age, gross type, degree of differentiation or lymph node metastases（P〉0.05）. The positive expression of VEGF was related to the degree of differentiation, FIGO staging and lymph node metastases（P〈0.05）, while was independent of age and gross type（P〉0.05）. Spearman correlation analysis revealed a significant positive correlation between positive VEGF expression and positive galectin-1 expression（r=0.949, P=0.004）. Conclusion The expression of galectin-1 and VEGF in cervical squamous cell carcinoma is related to tumor malignancy and metastasis, and serves as a potential new target for clinical treatment.
作者
邓晓燕
林海燕
陈卫国
DENG Xiaoyan;LIN Haiyan;CHEN Weiguo(First Clinical Medical School,Southern Medical University,Guangzhou 510515,Guangdong,China;Department of Ultrasonic Medicine;Department of Gynecology,the Fifth Affiliated Hospital of Southern Medical University,Guangzhou 510900,Guangdong,China;Department of Radiology,Southern Hospital,Nanjing Medical University,Guangzhou 510515,Guangdong,China)
出处
《癌症进展》
2018年第10期1278-1280,共3页
Oncology Progress
