摘要
目的探讨胃食管反流性咽喉疾病与幽门螺旋杆菌(Hp)感染的相关性.方法以220例胃食管反流性疾病患者为对象,依据患者是否合并咽喉疾病分为合并组和未合并组,纳入患者均行Hp检测,并对胃食管反流性咽喉疾病与Hp感染进行相关性分析.结果合并组Hp阳性检出率明显高于未合并组(P<0.05);两组性别、年龄、病程比较无明显差异(P>0.05);合并组Hp感染程度明显高于未合并组,差异显著(P<0.05),Hp感染是胃食管反流性咽喉疾病的独立危险因素(OR=2.633,P=0.012,95%CI 1.002～4.512); Spearman相关分析提示:胃食管反流性咽喉疾病发生率与Hp阳性率呈明显的正相关(r=0.451,P<0.05).结论胃食管反流性咽喉疾病与Hp感染有明显的相关性,临床对胃食管反流性咽喉疾病诊治时应首先筛查Hp.
Objective To investigate the correlation between gastroesophageal reflux laryngopharyngeal diseaseand Helicobacter pylori （Hp） infection. Method A total of 220 patients with gastroesophageal reflux diseasewere selected as the subjects. According to the presence of laryngopharyngeal disease,they were divided into thecomplication group and the non-complication group. The detection of Hp was performed,and the correlation betweengastroesophageal reflux laryngopharyngeal disease and Hp infection was analyzed. Results The positive rate of Hpin the complication group was significantly higher than that in the non-complication group （P〈0. 05）. There was nosignificant difference in gender,age and course of disease between the two groups （P〉0. 05）. The degree of Hpinfection in the complication group was significantly higher than that in the non-complication group （P〈0. 05）. Hpinfection was an independent risk factor for gastroesophageal reflux laryngopharyngeal disease （OR = 2. 633,P =0. 012,95%CI 1. 002-4. 512）. Spearman correlation analysis showed that the incidence of gastroesophageal refluxlaryngopharyngeal disease was obviously positively correlated with the positive rate of Hp （r = 0. 451,P〈0. 05）.Conclusion There is an obvious correlation between gastroesophageal reflux laryngopharyngeal disease and Hpinfection. In the clinical diagnosis and treatment of gastroesophageal reflux laryngopharyngeal disease,Hp should bescreened firstly,which is conducive to the formulation of reasonable treatment plan.
作者
王玲
罗伟
张雪莲
Wang Ling;Luo Wei;Zhang Xuelian(The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)
出处
《北华大学学报（自然科学版）》
CAS
2018年第6期792-795,共4页
Journal of Beihua University（Natural Science）
基金
成都市医学科研基金课题(2017118)
关键词
胃食管反流病
咽喉疾病
幽门螺旋杆菌
相关性
gastroesophageal reflux disease
laryngopharyngeal disease
helicobacter pylori
correlation
