摘要
目的 探讨美托洛尔联合贝那普利治疗老年原发性高血压合并慢性心力衰竭的效果.方法 选取2016年10月至2017年8月湛江中心人民医院收治的72例老年高血压合并心力衰竭患者,将其随机分为观察组、对照组1和对照组2,每组24例.对照组1服用美托洛尔片,对照组2服用贝那普利片,观察组同时服用美托洛尔片联合贝那普利片.连续治疗6个月,对比三组患者治疗效果、血压、心脏彩色多普勒超声指标、6 min步行距离及不良反应发生情况等.结果 三组治疗前各项指标比较差异未见统计学意义（P〉0.05）;治疗后6个月,观察组临床疗效、血压、心功能指标等较对照组1和对照组2改善更明显且差异有统计学意义（P〈0.05）.三组不良反应发生情况比较差异未见统计学意义（P〉0.05）.结论 美托洛尔联合贝那普利片能够有效改善老年高血压合并心力衰竭患者的临床疗效,改善其血压和心功能指标且不会增加患者不良反应,值得进一步推广应用.
Objective To investigate the effects of metoprolol combined with benazepril on elderly patients with primary hypertension and heart failure .Methods Seventy-two elderly patients with hypertension and heart failure treated in People ＇s Central Hospital of Zhanjiang from October 2016 to August 2017 were selected and were randomly divided into observation group , control group 1 and control group 2, with 24 cases in each group.Patients in control group 1 were treated with metoprolo, patients in control group 2 were treated with benazepril , patients in observation group were treated with metoprolol combined with benazepril .After 6 months of treatment , the therapeutic effects , blood pressure , color Doppler ultrasound cardiogram index , 6-minute walk distance and adverse reactions were compared among the three groups .Results There was no statistical difference in any test indexes among the three groups before treatment （ P〉0.05 ） .After 6 months of treatment , the improvement on clinical curative effect, blood pressure and cardiac function index of observation group were more obvious than those of control group 1 and control group 2, and the difference among the three groups was statistically significant （ P〈0.05 ） .There was no significant difference in the incidence of adverse reactions among the three groups （ P〉0.05 ） .Conclusions Metoprolol combined with benazepril can effectively improve the clinical efficacy for elderly patients with hypertension and heart failure , and it can improve their blood pressure and cardiac function , without increasing the adverse reaction of the patients .It is worthy of further application .
作者
李连珠
梁东华
蔡柳春
Li Lianzhu;Liang Donghua;Cai Liuchun(Department of Geriatrics,People＇s Central Hospital of Zhanjiang,Zhanjiang 524000,China)
出处
《中国实用医刊》
2018年第17期117-119,共3页
Chinese Journal of Practical Medicine
