摘要
目的探讨体外冲击波治疗中晚期老年膝关节骨关节炎（KOA）的疗效及对患者血清白细胞介素-6（IL-6）和白细胞介素-8（IL-8）水平的影响。方法选取2017年7月至2018年5月山西医科大学第一医院KOA患者80例，按随机数字表将其分为对照组和治疗组，每组40例。对照组采用硫酸氨基葡萄糖胶囊口服治疗，0．5∥次，3次／d。治疗组在对照组基础上行体外冲击波治疗，2次／周。两组连续治疗6周。比较两组西安大略和麦克马斯特大学骨关节炎指数（WOMAC指数）、临床疗效及安全性。检测两组血清IL-6和IL-8水平。结果治疗后，治疗组WOMAC量表指标（关节疼痛、关节僵硬、日常活动受限）评分和WOMAC总分少于对照组（P〈0．01）。治疗后6周，治疗组总有效率（92．50％）高于对照组（72．50％，P〈0．05）。疗程中，对照组不良反应发生率（7．50％）与治疗组（15．0％）比较差异未见统计学意义（P〉0．05）。治疗组治疗后血清IL-6和IL-8低于对照组（P〈0．01）。结论在常规治疗基础上，体外冲击波治疗中晚期老年KOA可明显缓解患者临床症状，提高临床疗效。且未明显增加不良反应，能降低患者IL-6和IL-8水平。
Objective To investigate the efficacy of extracorporeal shock wave on knee osteoarthritis （KOA） with middle and advanced stage in aged cases and its effect on serum levels of interleukin-6（IL-6） and interleukin-8 （IL-8）. Methods Eighty KOA patients in the First Affiliated Hospital of Shanxi Medical University from July 2017 to May 2018 were selected and randomly divided into control group and treatment group by random number table, with 40 cases in each group. The patients in the control group were orally given Glucosamine sulfate capsules （0. 5 g per time, tid）. On basis of control group, the treatment group was treated with extracorporeal shock wave, once a week. The two groups were treated for 6 weeks. Scores of the Western Ontario and McMaster Universities （WOMAC） , the efficacy and the safety were compared between the two groups. The serum levels of IL-6 and IL-8 were detected in the two groups. Results After treatment, the WOMAC score （joint pain, joint stiffness, limited daily activity） and total WOMAC score in the treatment group were significantly lower than those in control group （P 〈 0. 01 ）. After 6 weeks of treatment, the total effective rate （92. 50% ） of treatment group was significantly higher than that in control group （72.50%, P 〈 0. 05 ）. During the course of treatment, the incidence of adverse reactions （7. 50% ） in the control group was not significantly different from that in the treatment group （ 15.00%, P 〉 0. 05 ）. The serum IL-6 and IL-8 levels in the treatment group were significantly lower than those in the control group （P 〈 0. 01 ）. Conclusions On basis of routine therapy, extracorporeal shock wave in treating KOA with middle and advanced stage in aged cases can ameliorate the symptoms, enhance the efficacy, and without significantly increase the adverse reactions, and can reduce the levels of IL-6 and IL-8.
作者
范晓洁
李平
赵爱玲
Fan Xiaojie, Li Ping, Zhao Ailing(Department of Orthopedics, the First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China)
出处
《中国实用医刊》
2018年第18期13-16,共4页
Chinese Journal of Practical Medicine
基金
山西省科技攻关项目（20150313012-7）
关键词
体外冲击波
中晚期
膝骨性关节炎
安全性
Extracorporeal shock wave
Middle and advanced stage
Knee osteoarthritis
Safety
