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Electro.chemical Synthesis of (Aza)indolines via Dehydrogenative [3+2] Annulatnon: Application to Total Synthesis of (±)-Hinckdentme At 被引量:12

Electro.chemical Synthesis of (Aza)indolines via Dehydrogenative [3+2] Annulatnon: Application to Total Synthesis of (±)-Hinckdentme At
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摘要 An electrochemical synthesis of functionalized (aza)indolines through dehydrogenative [3+2] annulation of arylamines with tethered alkenes has been developed. Previous reported syntheses through similar inter- and intramolecular annulation reactions required noble-metal catalysts and are mostly limited to terminal alkenes or 1,3-dienes. The electrosynthesis employs the easily available and inexpensive ferrocene as the molecular catalyst and is compatible with di-, tri- and even tetrasubstituted alkenes to construct indolines as well as the more challenging azaindolines. Employing the newly developed electrosynthesis as a key step, the total synthesis of marine alkaloid (+)-hinckdentine A has been achieved in 12 steps (longest linear sequence) from commercially available materials. An electrochemical synthesis of functionalized (aza)indolines through dehydrogenative [3+2] annulation of arylamines with tethered alkenes has been developed. Previous reported syntheses through similar inter- and intramolecular annulation reactions required noble-metal catalysts and are mostly limited to terminal alkenes or 1,3-dienes. The electrosynthesis employs the easily available and inexpensive ferrocene as the molecular catalyst and is compatible with di-, tri- and even tetrasubstituted alkenes to construct indolines as well as the more challenging azaindolines. Employing the newly developed electrosynthesis as a key step, the total synthesis of marine alkaloid (+)-hinckdentine A has been achieved in 12 steps (longest linear sequence) from commercially available materials.
出处 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2018年第10期909-915,共7页 中国化学(英文版)
关键词 ELECTROCHEMISTRY INDOLINE RADICAL ANNULATION hinckdentine A electrochemistry indoline radical annulation hinckdentine A
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