摘要
对1例在用药过程中发生药物性肝损伤的慢性阻塞肺疾病(COPD)患者的病例进行分析及用药监护,探讨临床药师在治疗过程中发挥的作用。通过对患者症状及各项辅助检查指标的观察、详细的问诊,从药动学、药效学及药物相互作用的角度,分析导致患者发生药物型肝损伤的原因,并提出治疗建议。患者的肝药酶基因型、左氧氟沙星与米诺环素联用等原因导致药物性肝损伤,经保肝治疗后肝功能恢复正常。临床药师参与治疗,可以提高用药的安全性及有效性。
To analyze and pharmaceutical care of one chronic obstructive pulmonary disease （COPD） patient with drug-induced liver injury during the course of medication, to investigate the role of clinical pharmacist in the treatment. Through the observation of the patients’ symptoms and various auxiliary examination indicators and detailed inquiry, the causes of drug-induced liver injury in patient from the perspective of pharmacokinetics, pharmacodynamics and drug interaction were anlayzed, and the treatment suggestions were put forward. Drug-induced liver injury was caused by the genotype of hepatic microsomal enzyme and the combination of Levofloxacin and Minocycline. The liver function returned to normal after liver protection treatment. The participation of clinical pharmacists in the treatment can improve the safety and effectiveness of the drugs.
作者
李雪静
李书谊
王思箭
LI Xue-jing;LI Shu-yi;WANG Si-jian(Department of Pharmacy,Shandong Energy Zaozhuang Mining Group Central Hospital,Zaozhuang 277000,China)
出处
《中国现代药物应用》
2018年第21期137-139,共3页
Chinese Journal of Modern Drug Application
关键词
药物性肝损伤
慢性阻塞性肺疾病
药学监护
保肝
Drug-induced liver injury
Chronic obstructive pulmonary disease
Pharmaceutical care
Liver preservation
