摘要
目的:尿路感染(UTI)患者血清微量元素改变与炎症细胞因子、氧化应激指标的相关性。方法:选择在我院诊断为下尿路感染的患者作为UTI组、体检的健康志愿者作为对照组,采集血清并测定微量元素、炎症细胞因子的含量,采集尿液并测定氧化应激指标的含量。结果:UTI组血清中锌(Zn)的含量明显低于对照组(P<0.05),铜(Cu)、硒(Se)、钙(Ca)、镁(Mg)的含量与对照组比较无显著性差异(P>0.05);UTI组血清中C反应蛋白(CRP)、淀粉样蛋白A(SAA)、降钙素原(PCT)、细胞间黏附分子-1(ICAM-1)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、白细胞介素-17(IL-17)、转化生长因子β1(TGF-β1)的含量以及尿液中丙二醛(MDA)、晚期蛋白氧化产物(AOPP)的含量均明显高于对照组且与血清中Zn的含量呈负相关(r=-0.514、-0.573、-0.475、-0.636、-0.612、-0.585、-0.492、-0.537、-0.611、-0.476、-0.542,P=0.015、0.011、0.024、0.007、0.009、0.010、0.020、0.014、0.009、0.024、0.013),尿液中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)的含量均明显低于对照组且与血清中Zn的含量呈正相关(r=0.592、0.657、0.610,P=0.010、0.002、0.009)。结论:尿路感染患者血清微量元素Zn显著降低且与疾病的发生及病程中炎症反应、免疫应答、氧化应激反应的异常密切相关。
Objective： To study the correlation between serum trace clement changes and levels of inflammatory cyto kines anti oxidative stress indexes in patients with urinary tract infection （UTI）. Methods： The patients who were diagnosed with lower urinary tract infection in Aerospace Central Hospital between March 2013 and December 2017 were selected as the UTI group and the healthy volunteers who received physical examination were selected as the control group. Serum was collect cd to measure the contents of trace elements and inflammatory cytokines, and urine was collected to measure the contents of oxidative stress indexes. Results： The content of Zinc （Zn） in serum of the UTI group was significantly lower than that of the control group （P〈0.05） , while the contents of Copper （Cu） , Selenium （Se） , Calcium （Ca） and Magnesium （Mg） were not significantly different from those of the control group （P〉0.05） ; the contents of C reactive protein （CRP）, amyloid protein A （SAA） , procalcitonin （PCT） , intercellular adhesion molecule-1 （ICAM-1） , interleukin -2 （IL-2） , interleukin-4 （IL-4） , inter leukin-5（IL-5） , interleukin-17 （IL-17） and transforming growth factor-β1 （TGF-β1 ） in serum as well as the contents of malon dialdchydc （MDA） and advanced oxidation protein product （AOPP） in urine of the UTI group were significantly higher than those of the control group and negatively correlated with the content of Zn in serum （r=- 0.51d, -0.573, -0.475, -0.636, -0.612,-0.585, -0.492,-0.537, -0.611, -0.476 and -0.542,P =0.015, 0.011, 0.024, 0.007, 0.009, 0.010, 0.090, 0.014, 0.009, 0.024 and 0.013）, while the contents of supcroxidc dismutasc （SOD）, glutathionc pcroxidasc （GSH-Px） and catalasc （CAT） in urine were significantly lower than those of the control group and positively correlated with the content of Zn in scrum （r=0.592, 0.657 and 0.610, P=0.010, 0.002 and 0.009）. Conclusion： Serum trace element Zn significantly decreases in patients with urinary tract infection and it is closely related to the occurrence of the disease as well as the abnormality of inflam mation, immune response and oxidative stress in the progression of the disease.
作者
曹清芸
贾振芳
CAO Qing-yun;JIA Zhen-fang(Department of Laboratory Medicine,Aerospace Central Hospital,Beijing 100049)
出处
《海南医学院学报》
CAS
2018年第19期1728-1731,1736,共5页
Journal of Hainan Medical University
基金
航天中心医院院级课题(20150721-YNQN-01)~~
关键词
尿路感染
微量元素
炎症反应
免疫应答
氧化应激反应
Urinary tract infcction
Tracc clcmcnts
Inflammatory rcaction
Immunc rcsponsc
Oxidativc strcss rcaction
