摘要
目的研究不同孕期初产妇甲状腺功能异常与尿碘水平的关系。方法回顾性分析我院2017年2月至10月收治的105例初产妇的临床资料,依据不同孕期分为孕早期组(38例)、孕中期组(37例)以及孕晚期组(30例)。观察比较三组孕妇的促甲状腺素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)水平,尿碘水平及频数分布,以及甲状腺功能减退症的发生率。结果孕早期组的TSH显著低于孕中期组和孕晚期组, FT4显著高于孕中期组和孕晚期组,孕中期组的FT4显著高于孕晚期组(均P <0.05);三组的FT3水平比较,差异无统计学意义(P>0.05)。孕早期组的尿碘水平显著低于孕中期组和孕晚期组,孕中期组的尿碘水平显著高于孕晚期组(均P <0.05);三组尿碘水平的频数分布比较,差异无统计学意义(P>0.05)。孕晚期组的甲状腺功能减退症发生率显著高于孕早期组和孕中期组(P <0.05)。结论初产妇碘量过高或过低均可对母体及胎儿产生不良影响,需在孕中期及孕晚期开展尿碘水平检测、甲状腺功能筛查,适当调整碘摄入量,以避免妊娠期间甲状腺疾病的发生。
Objective To study the relationship between thyroid dysfunction and urinary iodine levels at different gestation in primiparas. Methods The clinical data of 105 primiparas in our hospital from February 2017 to October 2017 were retrospectively analyzed. According to different gestation, 105 primiparas were divided into first trimester group （38 cases）, second trimester group （37 cases） and late trimester group （30 cases）. The levels of thyroid stimulating hormone （TSH）, free thyroxine （FT4） and free triiodothyronine （FT3）, as well as the urinary iodine level and frequency distribution, and the incidence of hypothyroidism were observed and compared among the three groups. Results The TSH level in the first trimester group was significantly lower than that in the other two groups, and the FT4 level was significantly higher than that in the other two groups （P 〈0.05）; The FT4 level in the second trimester group was significantly higher than that in the late trimester group （P 〈0.05）; No significant difference was found in the FT3 level among the three group （P 〉0.05）. The urinary iodine level in the first trimester group was significantly lower than that in the other two groups, and the urinary iodine level in the second trimester group was significantly higher than that in late trimester group （P 〈0.05）; No significant difference was found in the frequency distribution of urinary iodine level among the three groups （P 〉0.05）. The incidence of hypothyroidism in the late trimester group was significantly higher than that in the other two groups （P〈0.05）. Conclusions If the iodine is too high or too low, it can have adverse effects on the mother and the fetus. It is necessary to carry out urine iodine level test and thyroid fimction screening in the second trimester and late trimester, and properly adjust the iodine intake to avoid thyroid disease during pregnancy.
作者
黄薇
HUANG Wei(Guangzhou Women and Children＇s Medical Center,Guangzhou 510623,China)
出处
《临床医学工程》
2018年第10期1375-1376,共2页
Clinical Medicine & Engineering
关键词
初产妇
甲状腺功能
不同孕期
尿碘水平
Primiparas
Thyroid function
Different gestation
Urinary iodine level
