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复方芪麻胶囊对高血压患者降压效应的Meta分析 被引量:1

Depressor Effect of Compound Qima Capsule on Hypertension:A Meta-Analysis
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摘要 目的:系统评价中药新药复方芪麻胶囊(QM)对原发性高血压(EH)的降压效应,为QM新药临床试验提供依据。方法:2018年7月31日前从CNKI、万方和维普数据库中检索出符合标准的全文文献:QM干预EH患者血压或24h动脉血压的随机对照(RCT)研究。在评价文献质量基础上提取数据,由RevMan 5.3软件进行Meta分析。结果:24篇中收治1963例(治疗组vs对照组:1047例vs 916例),其中16篇(735例vs 626例)、22篇(955例vs 872例)、4篇(168例vs 167例)分别观察降压临床疗效、血压和24h动态血压;与对照组比较,治疗组SBP、24hSBP、dSBP、dDBP、nSBP均有显著性降低(P<0.01),而DBP和24hDBP、nDBP均无显著性差异(P>0.05),降压疗效有显著性改善(P<0.01)。结论:QM单独或合用降压西药主要降低SBP、辅助性降低DBP,从而改善降压效果。 Objective: To systematically evaluate the anti-hypertensive effect of compound Qima capsule(QM) on essential hypertension(EH), in order to provide evidence for QM's clinical experiment. Methods: According to the inclusive criteria, full-text literatures about randomized controlled trials(RCT) for intervention on blood pressure or 24 h arterial pressure with QM in EH patients were searched from database of CNKI, Wanfang Data and VIP, which deadline was July 31, 2016. Based on the evaluation of literature quality, studies data were extracted to conduct a Meta-analysis with RevMan 5.3 software. Results: 1963 patients were treated in 24 articles(treatment group vs control group: 1047 vs 916), including 16 articles of observation on anti-hypertension effect(735 vs 626), 22 articles on blood pressure(955 vs 872) and 4 articles on 24 h arterial pressure(168 vs 167);compared with control group, the SBP, 24 hSBP, d SBP, dDBP, nSBP of treatment group were significantly decreased(P〈0.01), while there was no statistical difference in DBP and 24 hDBP, n DBP(P〉0.05), but the anti-hypertensive effect was significantly improved(P〈0.01). Conclusion: Single use of QM or combination with anti-hypertensive drugs mainly reduces SBP and auxiliarily reduces DBP to improve the depressor effect.
作者 赵自明 任薇 杜建平 夏能能 ZHAO Zi-ming;REN Wei;DU Jian-ping;XIA Neng-neng(Guangdong Research Institute of Traditional Chinese Medicine Manuracturing Technology(Guangdong Provincial Key Laboratory of R&D in TCM),Guangzhou,Guangdong 510095)
出处 《按摩与康复医学》 2018年第24期47-52,共6页 Chinese Manipulation and Rehabilitation Medicine
基金 广东省科技重大专项 编号:2010A030100007
关键词 原发性高血压 复方芪麻胶囊 降压效果 血压 24H动态血压 META分析 essential hypertension compound Qima capsule depressor effect blood pressure 24h arterial pressure Meta-analysis
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