摘要
目的:综述3D生物打印支架材料的研究进展和应用。方法:应用计算机检索PubMed数据库关于3D生物打印支架材料的文章,检索词为"3D bioprinting, scaffold"。结果与结论:3D生物打印技术具有快速成型、精确控制等特点,而且可以应用于个性化治疗。天然材料和复合材料可制备成生物墨水用于3D生物打印,通过化学修饰和交联、多种材料复合可提高材料力学和生物性能。利用3D生物打印可以构造精密、复杂的组织结构。在再生医学领域,3D生物打印有广阔的发展前景。
Objective： To review research progress and application of scaffold materials for 3-dimensional （3D） bioprinting. Methods： A computer-based retrieval was performed to search articles addressing scaffold materials for 3D bioprinting published in PubMed database by using the keywords of＂bioprinting＂, ＂scaffold＂. Result and Conclusion： The 3D bioprinting possesses the characteristics of rapid prototyping and precise control and can be applied to personalized treatments. Natural and synthetic materials can be used to prepare bioink for the 3D bioprinting. The mechanical and biological properties of the materials can be improved by chemical modification and cross-linking. Complex and precise tissue structure can be fabricated by the 3D bioprinting. It is believed that the 3D bioorinting has a meat prospect in the field of regenerative medicine.
作者
史建峰
王涵
赵蕾
韩倩倩
王春仁
Shi Jianfeng;Wang Han;Zhao Lei;Han Qianqian;Wang Chunren(National Institutes for Food and Drug Control,Beijing 102629,China)
出处
《中国药事》
CAS
2018年第10期1406-1411,共6页
Chinese Pharmaceutical Affairs
基金
国家重点研发计划-华南生物医用材料与植入器械创新示范基地(编号2017YFC1105000)
中国食品药品检定研究院学科带头人基金-三维打印体内全降解血管支架的质量控制和支架材料的血管内皮化机理研究(编号2015X2)
