摘要
目的分析晚期结直肠癌肝转移临床介入治疗效果。方法选取该院2014年2月—2015年2月收治的晚期结直肠癌肝转移患者80例作为观察对象,按照随机数字表法将患者分为对照组(n=40)和综合组(n=40),对照组患者接受TACE单独介入治疗,综合组患者接受综合介入治疗,观察比较两组患者治疗前后肿瘤标志物CEA含量,近期疗效和生存状况,首次治疗前后免疫功能指标情况。结果综合组患者治疗缓解率、1年后生存率、2年后生存率分别为92.50%、95.00%、70.00%,对照组患者治疗缓解率、1年后生存率、2年后生存率分别为72.50%、72.50%、50.00%,综合组患者近期疗效、生存状况均优于对照组患者,(χ~2=5.541 1、7.439 7、4.177 9、P=0.019、0.00 6、0.04 1);经过治疗后综合组患者CD3+阳性细胞、CD4+阳性细胞、CD8+阳性细胞、CD4+/CD8+、CEA含量分别为(59.22±3.18)%、(39.35±3.10)%、(15.40±2.52)%、(2.42±0.41)、(10.50±8.60)μg/L,均显著优于对照组患者(P<0.05)。结论对晚期结直肠癌肝转移患者实施介入治疗效果显著,值得推广。
Objective To analyze the clinical interventional effect of liver metastasis of advanced colorectal cancer. Methods 80 patients with advanced colorectal cancer liver metastasis from February 2014 to February 2015 were enrolled in the hospital. The patients were divided into control group （n=40） and comprehensive group （n=40） according to the random number table method, patients in the control group received TACE alone, and the patients in the comprehensive group underwent comprehensive interventional therapy. The CEA levels of tumor markers before and after treatment, the short-term efficacy and survival status, and the immune function indicators before and after the first treatment were compared. Results The treatment response rate, survival rate after 1 year, and survival rate after 2 years were 92.50%, 95.00%, and 70.00%, respectively. The treatment response rate, survival rate after 1 year, and survival rate after 2 years were respectively in the control group of 72.50%, 72.50%, and 50.00%, the short-term efficacy and survival of the comprehensive group were better than those of the control group （χ2=5.541 1, 7.439 7, 4.177 9, P=0.01 9, 0.006, 0.041）; after treatment, the CD3＋ positive cells and CD4＋ were positive in the comprehensive group. The contents of cells, CD8＋ positive cells, CD4＋/CD8＋ and CEA were （59.22±3.18）%, （39.35±3.10）%, （15.40±2.52）%, （2.42±0.41）, （10.50±8.60） μg/L, respectively. They were significantly better than the control group （P〈0.05）. Conclusion Interventional therapy for patients with advanced colorectal cancer with liver metastases is effective and worthy of promotion.
作者
刘东宇
LIU Dong-yu(Department of Catheter,Affiliated Hospital of Chifeng College,Chifeng,Inner Mongolia,024000 China)
出处
《系统医学》
2018年第19期142-144,共3页
Systems Medicine
关键词
晚期
结直肠癌肝转移
临床介入治疗
Advanced
Colorectal cancer liver metastasis
Clinical interventional therapy
