摘要
目的分析叶酸和维生素B_(12)联合治疗对血管性痴呆伴H型高血压患者血浆Hcy、炎性因子水平及血管壁内皮功能的影响效果。方法选择本院2016年4月～2018年4月收治的80例血管性痴呆伴H型高血压患者作为研究对象,并以随机数表法分成观察组与对照组各40例。对照组患者口服依那普利片治疗,观察组口服依那普利片、叶酸片及VB_(12)治疗。对比两组患者治疗后血浆Hcy和炎性因子情况、血管壁内皮功能各项指标情况及血压和MMSE评分情况。结果治疗后,观察组血浆Hcy和炎性因子水平值均明显低于对照组(P<0.05);NO水平值明显高于对照组(P<0.05),ET-1水平值明显低于对照组(P<0.05);两组治疗后血压对比差异无统计学意义,但观察组治疗后MMSE评分明显高于对照组(P<0.05)。结论叶酸和维生素B_(12)联合治疗血管性痴呆伴H型高血压,对患者血浆Hcy、炎性因子及血管壁内皮功能具有积极影响,值得临床推广。
Objective To analyze the effects of folic acid and vitamin B12 on plasma Hcy, inflammatory factors and endothelial function of vascularwall in patients with vascular dementia and H-type hypertension. Methods Eighty patients with vascular dementia and H-type hypertension admittedto our hospital from April 2016 to April 2018 were enrolled in the study. The patients were divided into observation group and control groupby 40 patients. The control group received oral enalapril tablets, and the observation group received oral enalapril tablets, folic acid tablets and VB12.The plasma Hcy and inflammatory factors, vascular wall endothelial function, blood pressure and MMSE scores were compared between the twogroups. Results After treatment, the levels of plasma Hcy and inflammatory factors in the observation group were significantly lower than those inthe control group （P〈0.05）; the NO level was significantly higher than the control group （P〈0.05）, and the ET-1 level was significantly lower thanthe control group. （P〈0.05）; there was no significant difference in blood pressure between the two groups after treatment, but the MMSE score inthe observation group was significantly higher than that in the control group （P〈0.05）. Conclusion The combination of folic acid and vitamin B12 inthe treatment of vascular dementia with H-type hypertension has a positive effect on plasma Hcy, inflammatory factors and endothelial function ofthe blood vessel wall, which is worthy of clinical promotion.
作者
王冀芳
Wang Jifang(Department of Cardiology,Huanggu District Maternal and Infant Hospital,Shenyang,Liaoning,110022,China)
出处
《当代医学》
2018年第31期71-73,共3页
Contemporary Medicine
