摘要
目的分析重庆地区艾滋病病毒（HIV）/丙型肝炎病毒（HCV）合并感染的发生率及危险因素;了解HIV合并慢性HCV感染者HCV-IgG抗体的产生情况,分析部分病人不能产生HCV-IgG的可能危险因素。方法回顾性收集HIV/HCV合并感染者资料,分析合并感染的可能危险因素;统计HIV合并慢性HCV感染者HCV-IgG阴性发生率,分析其HCV-IgG阴性的可能危险因素。结果 3 013例HIV感染者/艾滋病病人中合并HCV感染192例（6.37%）;合并感染HCV者的HIV病毒载量[（4.97±0.89）log拷贝/mL]低于单纯HIV感染者[（5.15±0.81）log拷贝/mL]（P〈0.05）;合并感染者中吸毒人数的比例（64.06%）高于单纯HIV感染者（0.92%）（P〈0.05）。合并感染者中13例（6.77%）HCV-IgG阴性。单因素分析显示,HCV-IgG阴性组较阳性组年龄偏大（P〈0.05）,HCV-IgG阴性组通过性途径导致感染所占比例（92.31%）高于阳性组（31.84%）（P〈0.05）;多因素分析显示,通过性途径导致合并感染者出现HCV-IgG阴性的风险,为通过静脉吸毒途径导致感染者的52.669倍。结论重庆地区HIV/HCV合并感染发生率较高,静脉吸毒是合并感染的高危因素;合并HCV感染可能抑制HIV复制;年龄、传播途径为HIV/HCV合并感染者产生HCV-IgG的危险因素,其中性传播为影响HCV-IgG产生的独立危险因素。
Objective To analyze the incidence and risk factors of HIV/HCV co-infection in Chongqing and to understand the status of HCV-IgG antibodies in HIV-positive patients.Risk factors were analyzed esp.among the patients who could not produce HCV-IgG antibodies.Methods Retrospective analysis was made based on the collected clinical data of HIV/HCV co-infected patients followed by the analysis of risk factors,and HCV-IgG negative incidence of HIV/HCV co-infection.Results Among the 3013 HIV-infected patients,192（6.4%）were infected with HCV.HIV/HCV co-infected patient（4.97±0.89 log copy/mL）had significantly lower HIV-RNA levels than the pure HIV-infected patients（5.15±0.81 log copy/mL）（P〈0.05）.The proportion of drug addicts in HIV/HCV co-infection（64.0%）was higher than that in HIV-infected patients（0.92%）（P〈0.05）.There were 13 cases（6.8%）of HCV-IgG negative in the HIV/HCV co-infected patients.Single factor analysis showed that HCVIgG negative group was older than the positive group（P〈0.05）,and the proportion of HCV-IgG negative group infected via sexual transmission（92.31%）was significantly higher than that of the positive group（31.84%）.Multivariate analysis showed that the risk of HCV-IgG negative in the co-infected group via sexual transmission was52.669 times greater than that by intravenous drug use.Conclusion The incidence of HIV/HCV co-infection in Chongqing is 6.4%,and intravenous drug use is a high risk factor for HIV/HCV co-infection.HCV infection may inhibit the replication of HIV-RNA.Age and route of transmission are risk factors for HCV-IgG in HIV/HCV infected patients, and sexual transmission is an independent risk factor for HCV-IgG.
作者
刘敏
何小庆
罗亚东
袁婧
吴玉珊
谭顺
王静
陈耀凯
LIUMin;HE Xiaoqing;LUO Yadong;YUAN Jing;WU Yushan;TAN Shun;WANG Jing;CHEN Yaokai(Chongqing Public Health Medical Center,Chongqing 400036,China)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2018年第8期828-830,834,共4页
Chinese Journal of Aids & STD
基金
重庆市卫生计生委医学科研计划项目(2017MSXM119)~~
