摘要
目的探讨染料木素铬配合物对2型糖尿病大鼠模型的治疗作用效果;方法制备大鼠2糖尿病模型,灌胃给予染料木素铬配合物15、30、60 mg/kg进行治疗,1次/d,连续5周,测试给药结束后,检测大鼠血清的糖代谢指标、脂代谢指标、肾功能指标,并对胰腺、肝、肾、视网膜等进行病理组织学检查。结果 1)染料木素铬配合物对2型糖尿病大鼠血清葡萄糖(GUL)、糖化血红蛋白(GHb)、三酰甘油(TG)、总胆固醇(TC)、尿素氮(UREA)、肌酐(CREA)均有明显的降低作用;2)组织病理学检测结果显示:染料木素铬配合物可以减轻糖尿病中胰腺、肝脏、视网膜的病变。结论染料木素铬配合物对2型糖尿病大鼠模型糖尿病相关生化指标及靶器官损害作用具有明显的改善作用。
Objective To investigate the effect of genistein/chromium complex in treating type-Ⅱ diabetes rats model. Methods After establishing type-Ⅱ diabetes rats model, rats were fed genistein/chromium complex with a gradient concentration（15 mg·kg-（-1）, 30 mg·kg-（-1）, 60 mg·kg-（-1）） by daily gavage administration for 5 weeks. At the end of administration, biochemical indexes were tested. Besides, pancreas, liver, kidneys, retina were harvested for pathological analysis. Results 1） Biochemical indexes including GUL, GHb, TC, TG, UREA, CREA expressed in serum were significantly decreased after giving genistein/chromium complex. 2） The pathological analysis showed that genistein/chromium complex could lighten the lesion of pancreas, liver and retina damaged by type-Ⅱ diabetes. Conclusion Genistein/chromium complex had an obvious improvement effect on diabetes related biochemical indexes and reduced damage of target organs in type-Ⅱ diabetes rats model.
作者
田建明
韦康
宋莲莲
解生旭
陈颖丽
徐雅娟
TIAN Jianming;WEI Kang;SONG Lianlian;XIE Shengxu;CHEN Yingli;XU Yajuan(Jilin Innovative Medicine Public Service Platform Co.,Ltd,Changchun 130012,China;Jilin Academy of Traditional Chinese Medicine and Material Medical Sciences,Changchun 130021,China)
出处
《吉林中医药》
2018年第10期1193-1195,共3页
Jilin Journal of Chinese Medicine
基金
吉林省科技厅重点科技攻关项目(20160204011YY)
