摘要
目的:探讨血清超敏C反应蛋白(hsCRP)、单核细胞趋化蛋白-1 (MCP-1)、C1q/肿瘤坏死因子相关蛋白9(CTRP9)、脂联素(APN)、脂蛋白磷脂酶A2 (Lp-PLA2)、Fractalkine (即趋化因子CX3C)、调节T细胞正常表达和分泌的细胞因子(RANTES)水平与无症状冠状动脉粥样硬化(ACAS)之间的关系。方法:选择我院2015年12月～2016年12月收治的50例ACAS患者作为ACAS组,另选同期50例正常体检者作为正常对照组。检测比较两组血清hsCRP、MCP-1、RANTES、CTRP9、APN、Lp-PLA2、Fractalkine水平。结果:与正常对照组比较,ACAS组血清CTRP9 [(3.70±1.20)×10-2 mg/L比(3.19±1.11)×10-2 mg/L]和APN [(3.85±1.15)mg/L比(3.28±1.01)mg/L]水平显著降低,hsCRP [(32.55±1.55)mg/L比(110.47±1.53)mg/L]、MCP-1 [(480.22±5.38)pg/ml比(600.47±5.43)pg/ml]、RANTES [(2.80±0.20)μg/ml比(4.19±0.22)μg/ml]、Lp-PLA2[(165.88±5.32)mg/L比(199.55±5.35)mg/L]和Fractalkine [(322.40±5.60)pg/ml比(500.64±5.66)pg/ml]水平显著升高,P<0.05或<0.01。结论:与正常对照组比较,无症状冠状动脉粥样硬化患者血清CTRP9和APN水平显著降低,血清hsCRP、MCP-1、RANTES、Lp-PLA2、Fractalkine水平显著升高。检测上述指标可为早期诊断及干预提供有力的科学依据。
Objective：To explore relationship among serum levels of high sensitive C reactive protein（hsCRP）,monocyte chemoattractant protein（MCP）-1,C1 q/tumor necrosis factor-related protein（CTRP）9,adiponectin（APN）,lipoprotein-associated phospholipase（Lp-PLA）2,Fractalkine（namely,chemotatic factorCX3 C）,regulated on activation,normal T-cell expressed and secreted（RANTES）and asymptomatic coronary atherosclerosis（ACAS）.Methods：A total of 50 ACAS patients,who were treated in our hospital from Dec 2015 to Dec 2016,were regarded as ACAS group.Another 50 healthy subjects were enrolled as normal control group.Serum levels of hsCRP,MCP-1,RANTES,CTRP9,APN,Lp-PLA2 and Fractalkine were measured and compared between two groups.Results：Compared with healthy control group,there were significant reductions in serum levels of CTRP9[（3.70±1.20）10-2 mg/L vs.（3.19±1.11）10-2 mg/L]and APN [（3.85±1.15）mg/L vs.（3.28±1.01）mg/L],and significant rise in serum levels of hsCRP[（32.55±1.55）mg/L vs.（110.47±1.53）mg/L],MCP-1 [（480.22±5.38）pg/ml vs.（600.47±5.43）pg/ml],RANTES[（2.80±0.20）μg/ml vs.（4.19±0.22）μg/ml],Lp-PLA2[（165.88±5.32）mg/L vs.（199.55±5.35）mg/L]and Fractalkine[（322.40±5.60）pg/ml vs.（500.64±5.66）pg/ml]in ACAS group,P〈0.05 or0.01.Conclusion：Compared with normal control group,there are significant reductions in serum levels of CTRP9 and APN,and significant rise in serum levels of hsCRP,MCP-1,RANTES,Lp-PLA2 and Fractalkine in ACAS patients.Detection of above indexes can provide strong evidence for early diagnosis and intervention.
作者
吴爱成
唐恒锋
黄国清
wu Ai- cheng; TANG Heng-feng; HUANG Guo-qing(Department of Laboratory, Central Hospital of Longhua District, Shenz- hen, Guangdong, 518110, China)
出处
《心血管康复医学杂志》
CAS
2018年第5期534-536,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
