摘要
骨膜是附着在骨质上的一层特殊结缔组织,不仅包含了骨质修复所需的间充质细胞,即骨膜源干细胞（PDSCs）,而且提供了PDSCs所需的微环境以及必要的生物力学支撑.骨膜在骨组织修复中起着至关重要的作用,临床上骨膜移植已广泛应用于骨质修复,是再生医学的重要研究领域.对骨膜的结构以及PDSCs的生物学特征进行了综述,概述两者在骨修复中的研究进展,探讨了PDSCs参与骨修复所涉及的相关信号通路.骨膜和PDSCs除了在骨修复中起着决定性作用外,还是影响骨质再生的重要因素之一.对比了PDSCs在人/小鼠断肢愈伤、蝾螈割处再生以及鹿茸完全再生过程中增殖及分化潜能的差异,发现PDSCs增殖潜能以及丰富的血液供给可能是决定骨质再生的关键因素.
The periosteum is a special connective tissue enveloping bone,which not only contains the mesenchymal cells required for bone repair,i.e.periosteum derived stem cells （PDSCs）,but also provides the microenvironment required for PDSCs and the necessary biomechanical support.Periostea play a vital role in bone tissue repair.Clinical periosteal transplantation has been widely applied to restore bone defects,which is an important research field in regenerative medicine.In this paper,the structure characters of periosteal cells isolation and characterization of PDSCs were reviewed.The research progress of periosteum and PDSCs in bone defect restoration was reviewed.The related signal pathways involved in the restoration of PDSCs were discussed.Periostea and PDSCs are not only crucial for bone defect repair but also play important role in bone regeneration.The differences in proliferation and differentiation potential of PDSCs in human/mouse amputation,the amphibian epimorphic regeneration and the annual regeneration of deer antler were compared and analyzed.The results showed that the proliferative potential of PDSCs and abundant blood supply may be the key factors determining bone regeneration.
作者
褚文辉
刘振
李春义
Chu Wenhui;Liu Zhen;Li Chunyi(Institute of Special A nimal and Plant Sciences,Changchun 130000,China)
出处
《国际生物医学工程杂志》
CAS
2018年第4期336-341,共6页
International Journal of Biomedical Engineering
关键词
骨膜
骨膜来源干细胞
骨质修复
骨质再生
Periostea
Periosteum derived stem cells
Repair of bone defects
Bone regeneration
