摘要
目的:评价健脾补肾活血方治疗脑梗死的临床疗效及其对外周血内皮祖细胞(EPCs)含量的影响。方法:采用随机数字表法把符合标准的72例患者分为治疗组(基础治疗+健脾补肾活血方)和对照组(基础治疗),每组36例,14 d为1个疗程。分别测定2组患者治疗前后中医证候改善量化积分、MBI评分、神经功能缺损评分(NIHSS)及外周血EPCs含量变化。结果:治疗后,治疗组外周血EPCs含量、MBI评分升高较对照组更明显,中医证候积分、NIHSS量表评分降低更明显,以上差异均有统计学意义(P <0. 05)。结论:健脾补肾活血方能升高脑梗死恢复期脾肾两虚型患者EPCs水平,明显改善中医证候、临床症状和体征,这可能与其动员骨髓中EPCs和增加外周血EPCs水平,从而促进梗死区血管修复再生。
Objective： To evaluate the clinical effect of the Jianpi Bushen Huoxue Fang treated on cerebral infarct and its influence on the levels of peripheral blood endothelial progenitor cells（ EPCs）. Methods： Will be included in the standard of 72 patients with cerebral infarct according to random number table method were randomly,divided into two average groups including the treatment group and the control group at random. The two groups were both treated with routine western medicine,besides this,the treatment group was dosed the Jianpi Bushen Huoxue Fang additionally,14 days is a period of treatment. Both groups were evaluated with the level of circulating EPCs from venous blood,TCM syndromes＇ score,the NIHSS scale,and MBI scale at the beginning and the end of the treatment. Results： The levels of EPCs and the MBI score of treatment group were improved more obviously than the control group,and the TCM syndromes＇ score and the NIHSS scale score of treatment group were declined more obviously than the control group. The difference was both statistically significant（ P 0. 05）. Conclusion： There are significant therapeutic effects of the Jianpi Bushen Huoxue Fang on patients with cerebral infarction at convalescence（ the type of deficiency of spleen and kidney）,such as improving circulating endothelial progenitor cells,the TCM syndromes,the clinical symptoms and signs of patients. Preliminary discussion that the probable mechanism of significant therapeutic is mobilizing EPCs in the bone marrow to migrate into the blood and homing to damaged tissue at cerebral infarction,therefore boosting repair of damaged blood vessels and angiogenesis of infarct region.
作者
刘向哲
王聪
王彦华
杨海燕
张燕平
LIU Xiang-zhe;WANG Cong;WANG Yan-hua;YANG Hai-yan;ZHANG Yan-ping(The First Affiliated Hospital of Henan University of TCM,Zhengzhou 450000,China;Nanyang Zhang Zhong,jing Hospital,Nanyang 473000,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2018年第20期2383-2388,共6页
Chinese Journal of New Drugs
基金
河南省科技攻关计划资助项目(132102310400
162102310103)
关键词
健脾补肾活血方
脑梗死
内皮祖细胞
Jianpi Bushen Huoxue Fang
cerebral infarction
endothelial progenitor cells
