摘要
目的探讨血清氨基末端B型钠尿肽原(NT-proBNP)在早产儿呼吸窘迫综合征(RDS)中检测的临床意义。方法根据RDS的诊断标准,将136例早产儿分成RDS组(114例)及对照组(无RDS等并发症的普通早产儿22例),并按照SA(Silverman Anderson)评分分值将RDS组分为轻度RDS组51例、中度RDS组52例和重度RDS组11例,运用电化学发光方法测定其血清中NT-proBNP的水平,对上述结果进行分析。结果对照组早产儿血清中NT-proBNP水平为1 610(880.25～2 805.25)pg/mL,而轻度RDS组升高为2 534(1 509.00～4 423.00)pg/mL,中度RDS组为5 168(2 639.75～9 216.25)pg/mL,重度RDS组为15 630(2 610.00～52 868.00)pg/mL,各RDS组与对照组比较,差异有统计学意义(P<0.05)。结论对早产儿RDS血清中NT-proBNP进行监测,可及早发现心功能下降情况,并有助于判断心力衰竭的程度,对RDS的抢救和治疗具有重要的临床意义。
Objective To determine the clinical significance of serum N-terminal B type natriuretic peptide （NT-proBNP） in premature infants with respiratory distress syndrome （RDS）. Methods According to the diagnostic criteria for premature infants with respiratory distress syndrome,136 cases of premature infants were divided into RDS group and control group （22 cases of common complications such as preterm infants without RDS）,and in accordance with the SA （Silverman Anderson） score group RDS 114 cases of RDS were divided into mild 51 cases （3-5）,moderate （6-7 points） 52 cases and 11 severe cases （8-10） of three groups,the determination of NT-proBNP in serum by Electrochemiluminescence Method,the results were analyzed. Results The control group in the plasma concentration of NT-proBNP protein in preterm infants was 1 610（880.25-2 805.25）pg/mL,and mild RDS group increased to 2 534（1 509.00-4 423.00）pg/mL,moderate RDS group was 5 168（2 639.75-9 216.25）pg/mL,severe RDS group was 15 630（2 610.00-52 868.00）pg/mL.Compared with the control group,each RDS group showed the significant difference （ P 〈0.001）. Conclusion Monitoring of NT-proBNP in serum of premature infants may reflect the severity of the impairment of cardiac function and myocardial damage in newborns with RDS.It has important clinical significance for the rescue and treatment of RDS.
作者
熊志刚
汤庆
钟元锋
李晨
李松
刘沛
陈俊昆
管青
XIONG Zhigang;TANG Qing;ZHONG Yuanfeng;LI Chen;LI Song;LIU Pei;CHEN Junkun;GUAN Qing(Department of Laboratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)
出处
《检验医学与临床》
CAS
2018年第22期3415-3417,共3页
Laboratory Medicine and Clinic
