摘要
目的:探讨早期盆底康复训练联合补中益气丸对产后女性盆底功能障碍(PFD)的防治效果及转化生长因子-β1(TGF-β1)及类胰岛素一号增长因子(IGF-1)水平的影响。方法:选取2016年1月至2017年6月南京医科大学附属淮安第一医院收治的经阴道分娩并确诊为PFD的产妇312例,随机分为观察组和对照组,每组156例。2组产妇均行Kegel训练及盆底康复治疗仪治疗,观察组同时给予补中益气丸,2组均连续治疗6周。统计临床疗效,于产后42 d(治疗前)、3个月、6个月统计2组气虚积分变化、盆底肌力康复情况、盆腔器官脱垂(POP)和压力性尿失禁(SUI)发生情况,并检测2组血清TGF-β1和IGF-1含量。结果:观察组总有效率为93. 58%显著高于对照组的75. 00%(P <0. 01)。与产后42 d比较,产后3个月、6个月气虚积分、POP和SUI发生率逐渐下降,且观察组低于对照组(P <0. 01); 2组盆底肌力逐渐增强,观察组盆底肌力增强程度显著高于对照组(P <0. 05或P <0. 01);产后3个月2组患者血清TGF-β1和IGF-1含量均升高,且观察组高于对照组(P <0. 01)。结论:产后早期盆底康复训练联合补中益气丸对产后女性PFD具有较好的防治效果,能够提高盆底肌力,降低POP和SUI发生率,可能与升高血清TGF-β1和IGF-1含量有关。
Objective：To explore the effects of early pelvic floor rehabilitation training combined with Buzhong Yiqi Pills on prevention and treatment and on the levels of transforming growth factor-β-i （TGF-β1） and insulin-like growth factor-1 （ICF-1） in postpartum women with pelvic floor dysfunction （PFD）. Methods ：A total of 312 cases of postpartum women diagnosed with PFD who had vaginal delivery and were treated in the Affiliated Huaian First Hospital of Nanjing Medical University were selected and randomly divided into observation group and control group with 156 cases in each group. The postpartum women in the 2 groups were treated with Kegel training and early pelvic floor rehabilitation training, on basis of which the observation group was given Buzhong Yiqi Pills simultaneously, and the 2 groups were treated for 6 weeks continuously. Clinical efficacy was statistically analyzed; qi deficiency scores changes, pelvic floor muscle strength recovery, the occurrence of pelvic organ prolapse （POP） and stress urinary incontinence （SUI） were statistically counted at 42 days （before treatment） ,3 months and 6 months after delivery; the serum levels of TGF-β1 and IGF-1 in the 2 groups were detected. Results ：The total effective rate in the observation group （93.58%） was significantly higher than that in the control group （75.00%） （ P 〈 0. 01 ）. Compared with 42 days, 3 months, and 6 months postpartum, the scores of qi deficiency, POP and SUI incidences in the 2 groups gradually decreased, and the observation group were lower than the control group （P 〈 0. 01 ） ; pelvic floor muscle strength in the 2 groups gradually increased, and pelvic floor muscle strength in the observation group increased more than the control group （P 〈 0. 05 or P 〈 0. 01 ） ; the levels of serum TGF-β1 and ICF-1 in the 2 groups increased at 3 months postpartum,and the observation group were higher than the control group （P 〈 0. 01 ）. Conclusion：Early pelvic floor rehabilitation training combined with Buzhong Yiqi Pills has good preventive and therapeutic effects in postpartum women with PFD,which can improve pelvic floor muscle strength and reduce POP and SUI incidence,which may be associated with the increase of serum TGF-β1 and IGF-1 content.
作者
王辰之
祁玉军
Wang Chenzhi;Qi Yujun(Department of Rehabilitation Medicine,The Affiliated Huaian First Hospital of Nanfing Medical University,Nanjing 223300,China)
出处
《世界中医药》
CAS
2018年第11期2737-2740,共4页
World Chinese Medicine
基金
南京医科大学科技发展基金项目(TS32873)--康复训练联合中药对产后女性盆底功能障碍的防治效果的影响
关键词
盆底功能障碍性疾病
补中益气丸
盆底康复训练
盆底功能
转化生长因子-Β1
类胰岛素一号增长因子
Pelvic floor dysfunction disease
Buzhong Yiqi Pills
Pelvic floor rehabilitation training
Pelvic floor function
Transforming growth factor-β1
Insulin-like growth factor-1
