摘要
目的:观察芪明颗粒对非增殖期糖尿病性视网膜病变(NPDR)的脉络膜循环的作用及其对干眼症的改善情况,并分析芪明颗粒部分作用机制。方法:选取2013年4月至2015年11月河北省人民医院眼科收治确诊的NPDR患者100例,根据治疗方法不同分为对照组(单纯使用羟苯磺酸钙治疗)和观察组(芪明颗粒联合羟苯磺酸钙治疗),每组50例。治疗2个月后,测量2组患者的组织因子(TF)、色素上皮衍生因子(PEDG)、胰岛素样生长因子-1(IGF-1)、血管内皮生长因子(VEGF)的浓度变化以及血清支链氨基酸的含量进行比较和分析。结果:1)对照组血清内TF、IGF-1,VEGF含量均显著高于观察组,而PEDF含量明显低于观察组,差异有统计学意义(P <0. 05)。2)对照组血清缬氨酸、异亮氨酸、亮氨酸的含量均显著高于观察组,差异有统计学意义(P <0. 05)。3)观察组临床总有效率92%,与对照组78%比较,差异有统计学意义(P <0. 05)。结论:芪明颗粒能够抑制视网膜内形成新生血管以及改善脉络膜循环,对患者的干眼症提供有效的治疗帮助。
Objective ： To observe the effects of Qiming Granules in the treatment of patients with NPDR choroid circulation and the improvement of dry eye, and to explore the mechanism of action. Methods ：A total of 100 patients with non-proliferation stage of diabetic retinopathy who were hospitalized in Hebei Provincial People＇s Hospital were selection from April 2013 to November 2015, and they were divided into control group （using pure hydroxyl benzene sulfonic acid calcium treatment） and observation group （ Qiming Granules with hydroxyl benzene sulfonic acid calcium therapy） with 50 cases in each group. After 2 months of treatment, the changes of tissue factor （TF）, pigment epithelium-derived factor （PEDG） ,insulin-like growth factor-1 （ IGF-1 ） ,vascular endo- thelial growth factor （VEGF） and serum branched-chain amino acids of the two groups were measured and compared for analysis. Results ：1 ）The serum TF, IGF-1 ,VEGF levels of the control group were significantly higher than that of observation group, but the content of PEDF was significantly lower than the observation group,with statistically significant difference （P 〈 0. 05 ）. 2）The serum contents of valine, isoleucine, leucine of the control group were significantly higher than that of the observation group, with statistically significant difference （ P 〈 0. 05 ）. 3 ） The total effective rate of the treatment group was 92% , which was significantly different from that of the control group （ 78 % ）, with statistically significant difference （ P 〈 0. 05 ）. Conclusion ： Qiming Granules can restrain formation of new blood vessels and improve choroid circulation,which can provide effective treatment for patients with dry eyes.
作者
赵智华
李科军
赵晓彬
马清敏
王明月
Zhao Zhihua;Li Kejun;Zhao Xiaobin;Ma Qingmin;Wang Mingyue(Department of Ophthalmology,Hebei Provincial People＇s Hospital,Shijiazhuang 050000,China;The Sixth Hospital of Chengde,Chengde 067200,China)
出处
《世界中医药》
CAS
2018年第11期2762-2765,2769,共5页
World Chinese Medicine
基金
河北省中医药管理局科研计划(20140154)
关键词
芪明颗粒
羟苯磺酸钙
糖尿病视网膜病变
非增殖期
干眼症
支链氨基酸
细胞因子
脉络膜循环
Qiming Granules
Calcium hydroxybenzene sulfonate
Diabetic retinopathy
Non-proliferation
Dryeye
Branchedchain amino acids
Cytokine
Choroidal circulation
