摘要
目的探讨硬膜外持续麻醉联合地塞米松对消化道肿瘤患者术后认知功能及躁动的影响。方法选取消化道肿瘤患者90例,随机分为对照组和观察组各45例。对照组采用硬膜外持续麻醉方式,观察组采用硬膜外持续麻醉联合地塞米松。应用简易精神状态评价量表(MMSE)评估2组患者术前及术后6、12 h的认知功能情况,比较2组患者苏醒期躁动评分。比较2组患者的麻醉效果。结果 2组患者术前MMSE评分无显著差异(P> 0. 05);术后6、12 h时,观察组MMSE评分均显著高于对照组(P <0. 05)。观察组患者苏醒期躁动评分显著低于对照组(P <0. 05);观察组术后6 h时炎性因子水平显著低于对照组(P <0. 05)。结论消化道手术中行硬膜外持续麻醉联合地塞米松可减少苏醒期躁动发生,降低对患者认知功能的影响。
Objective To investigate the effect of continuous epidural anesthesia combined with dexamethasone on postoperative cognitive function and dysphoria in patients with digestive tract tumors. Methods A total of 90 patients with digestive tract tumors were selected and randomly divided into control group and observation group, with 45 cases in each group. The control group was conducted with continuous epidural anesthesia, while the observation group was conducted with continuous epidural anesthesia and dexamethasone. Mini-mental State Examination （MMSE） was used to assess the cognitive function before treatment and 6, 12 hours after the operation in both groups, and the score of dysphoria in awakening period and anesthetic effect were compared between the two groups. Results There was no significant difference in MMSE score before operation between the two groups （ P 〉0.05）, but the MMSE scores at 6 and 12 hours after operation in the observation group were significantly higher than the control group （ P 〈0.05）. The scores of dysphoria in awakening period in the observation group were significantly lower than that in the control group （ P 〈0.05）, and the levels of inflammatory factors at 6 hours after operation in the observation group were significantly lower than those in the control group （ P 〈0.05）. Conclusion Continuous epidural anesthesia combined with dexamethasone in digestive tract surgery can reduce incidence of dysphoria in awakening period and influence on cognitive function.
作者
王臻
张世平
朱婧
WANG Zhen;ZHANG Shiping;ZHU Jing(Department of Anesthesiology,Shaanxi Provincial People′s Hospital,Xi′an,Shaanxi,710068)
出处
《实用临床医药杂志》
CAS
2018年第22期37-39,共3页
Journal of Clinical Medicine in Practice
关键词
消化道肿瘤
硬膜外麻醉
地塞米松
简易精神状态评价量表
苏醒期
躁动
digestive tract tumors
epidural anesthesia
dexamethasone
Mini-mental State Examination
awakening period
dysphoria
