妊娠期初诊甲状腺功能减退的孕前相关危险因素分析被引量：3

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摘要目的:寻找预测妊娠期初诊甲状腺功能减退(甲减)的独立危险因素。方法:回顾性分析30例妊娠期初诊甲减患者及30例妊娠期甲状腺功能正常妇女的孕前临床资料,分析比较两组患者年龄、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、甲状腺功能指标(TSH和FT4)、甲状腺过氧化物酶抗体(TPO-Ab)、甲状腺球蛋白抗体(TGAb)、促甲状腺受体抗体(TR-Ab)、尿碘浓度(UI)、甲状腺超声检查结果、甲亢或甲减家族史。结果:单因素相关分析提示TPO-Ab、TG-Ab、甲亢或甲减家族史、超声甲状腺斑片状回声改变与妊娠期初诊甲减密切相关,多因素logistic回归分析提示孕前TPO-Ab水平、超声甲状腺斑片状回声改变是妊娠期初诊甲减发生的独立预测危险因素。结论:孕前TPO-Ab水平、超声甲状腺斑片状回声改变可以预测妊娠期初诊甲减的发生,有助于指导妊娠妇女孕早期密切监测甲状腺功能水平,及早干预治疗,减少围生期可能并发症。

作者黄海燕王春华王雪琴徐峰王咏梅乔海风苏建彬

机构地区南通市第一人民医院内分泌科南通市第一人民医院妇产科

出处《交通医学》 2018年第5期503-505,共3页 Medical Journal of Communications

关键词妊娠期甲状腺功能减退甲状腺过氧化物酶抗体甲状腺超声

分类号 R581.2 [医药卫生—内分泌]

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1李建新,王森,单忠艳,王薇薇,滕卫平.妊娠早期母体甲状腺功能及其抗体异常对妊娠结局的影响[J].中华内分泌代谢杂志,2011,27(11):916-919. 被引量：56
2高劲松,边旭明.妊娠合并甲状腺功能减退症的研究进展[J].中华妇产科杂志,2012,47(9):697-700. 被引量：78
3史晓光,韩成,李晨嫣,毛金媛,王薇薇,解晓晨,周卫卫,李晨阳,毕丽华,孟涛,张绍维,杜建玲,高政南,张晓梅,范晨玲,单忠艳,滕卫平.妊娠早期妇女甲状腺自身抗体分析[J].中华内分泌代谢杂志,2016,32(5):376-379. 被引量：26

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