摘要
目的:观察经鼻双水平正压通气(nBiPAP)治疗早产儿呼吸暂停(AOP)的临床效果。方法:选取2014年1月-2018年5月本院收治的AOP患儿78例,根据治疗方法不同将其分为治疗组(n=38)和对照组(n=40)。对照组采用经鼻持续气道正压通气(nCPAP)进行呼吸支持,治疗组采用n BiPAP进行呼吸支持。比较两组呼吸暂停缓解率、治疗无效后气管插管率、总用氧时间及并发症发生情况。结果:治疗组呼吸暂停缓解率为55.3%,明显高于对照组32.5%(P<0.05);治疗组的治疗无效后气管插管率为7.9%,低于对照组27.5%(P<0.05);两组用氧总时间比较差异无统计学意义(P>0.05);两组颅内出血、气胸、鼻压伤、新生儿坏死性小肠结肠炎(NEC)、支气管肺发育不良(BPD)的发生率比较,差异均无统计学意义(P>0.05)。结论:NBiPAP治疗AOP与NCPAP相比具有显著的疗效,且安全性相当,值得临床推广应用。
Objective： To evaluate the clinic effect of nasal bi-level positive pressure ventilation（nBiPAP） on apnea of premature infants（AOP）.Method：A total of 78 children with AOP from January 2014 to May 2018in our hospital were selected.According to different treatment methods,they were divided into treatment group（n=38） and control group（n=40）.The control group was given nasal continuous positive airway pressure（nCPAP） for respiratory support,while treatment group was given nBiPAP for respiratory support.The apnea remission rate,endotracheal intubation rate after failure of treatment,total oxygen time and complications between two groups were compared.Result：The apnea remission rate in treatment group was 55.3%,higher than 32.5% in control（P〈0.05）.The endotracheal intubation rate after failure of treatment in treatment group was 7.9%,which was lower than 27.5% of control group（P〈0.05）.The total oxygen time in two groups were compared,the difference was not statistically significant（P〉0.05）.The incidence of intracranial hemorrhage,pneumothorax,nasal crush,neonatal necrotizing enterocolitis （NEC） and bronchopulmonary dysplasia（BPD） in two groups were compared,the differences were not statistically significant（P〉0.05）.Conclusion： nBiPAP has a significant effect compared with NCPAP in treatment of AOP,and good safety,which is worth clinical spread application.
作者
沈莉莉
SHEN Lili(Suzhou Kowloon Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Suzhou 215000,China)
出处
《中国医学创新》
CAS
2018年第32期35-38,共4页
Medical Innovation of China
关键词
早产儿
呼吸暂停
持续气道正压通气
经鼻双水平正压通气
Premature infant
Apnea
Continuous positive airway pressure
Nasal bi-level positive pressure ventilation
