摘要
恶性疟原虫引起的恶性疟是一种严重危害人类健康的寄生虫病,采用疫苗防治该病是当前研究的热点领域之一。PfMSP-1抗原是一种有效的疫苗候选分子,鼠伤寒沙门菌、卡介苗、酵母菌、根癌农杆菌、嗜热四膜菌、腺病毒、牛痘病毒和杆状病毒等微生物经过改造后均可成为有希望的疫苗载体。本文综述了重组鼠伤寒沙门菌(rSt-PfMSP-1和rSt-PfMSP-1_(19))、重组BCG疫苗(rBCG-PfMSP-1c和rBCGPfMSP-1_(19))、重组酵母菌(rPp-PfMSP-1)、重组根癌农杆菌(rAt-PfMSP-1_(42)、rAt-PfMSP4/5和rAtPf38)、重组嗜热四膜菌(rTt-PfMSP-1_(19))、重组腺病毒(rAd5-PfMSP-1_(42)和rChAd63-PfMSP-1)、重组牛痘病毒(rVV-PfMSP-1和rVV-PfHGFSP)以及重组杆状病毒(rBDES-PfMSP-1_(19))的构建及其免疫机制的研制现状。
Falciparum malaria caused by Plasmodium falciparum is one type of parasitic diseases seriously endangering human health.To control this parasite by use of vaccine has recently become a hotspot of research.PfMSP-1 antigen is an effective candidate molecule of vaccines,and many microorganisms such as Salmonella typhimurium,Bacillus calmette-Guerin,Pichia pastoris,Agrobacterium tumefaciens,Tetrahymena thermophila,Adenovirus,Vaccinia virus and Baculovirus may become hopeful vehicles after they are modified.This article reviews the current status of the research on the construction and immune mechanisms of these vaccines including rSt-PfMSP-1,rSt-PfMSP-119,rBCG-PfMSP-1 c,rBCG-PfMSP-119,rPpPfMSP-1,rAt-PfMSP-142,rAt-PfMSP4/5,rAt-Pf38,rTt-PfMSP-119,rAd5-PfMSP-142,rChAd63-PfMSP-1,and rBDES-PfMSP-119.
作者
李文桂
陈雅棠
LI Wengui;CHEN Yatang(Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《中国微生态学杂志》
CAS
CSCD
2018年第10期1226-1230,1234,共6页
Chinese Journal of Microecology
基金
国家自然科学基金(30801052
30671835
30500423
30200239)
