摘要
目的:观察牛黄清心丸辅助治疗急性脑出血的临床疗效及对患者体内血清S100B蛋白(S-100B)和神经肽Y (NPY)水平的影响。方法:将86例急性脑出血患者按随机数字表法分为治疗组和对照组各43例。对照组予常规治疗方案加盐酸纳洛酮注射液治疗,治疗组在对照组基础上加服牛黄清心丸。观察2组治疗前后美国国立卫生院卒中量表(NIHSS)、格拉斯哥昏迷量表(GCS)及中医症状评分的变化,对比分析2组临床疗效,检测2组治疗前后血清S-100B、NPY水平。结果:治疗后,2组NIHSS评分均较治疗前降低(P <0.01),GCS评分均较治疗前升高(P <0.01);治疗组NIHSS评分低于对照组(P <0.01),GCS评分高于对照组(P <0.01)。治疗后,2组头晕目眩、偏身麻木、便干便秘、痰多评分均较治疗前降低(P <0.01);治疗组上述4项中医症状评分均低于对照组(P <0.01)。治疗组总有效率74.42%,对照组总有效率55.81%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组血清S-100B、NPY水平均较治疗前降低(P <0.01);治疗组血清S-100B、NPY水平均低于对照组(P <0.01)。结论:牛黄清心丸辅助治疗急性脑出血可有效改善患者的神经功能及意识状况,提高治疗效果,作用机制可能与调节体内S-100B、NPY水平有关。
Objective： To observe the clinical effect of Niuhuang Qingxin pills in adjuvant treatment for acute cerebral hemorrhage and the effect on levels of S100B protein （S-100B） and neuropeptide Y （NPY） in serum of patients. Methods： Divided 86 cases of patients with acute cerebral hemorrhage into the treatment group being 43 cases and the control group being 43 cases randomly according to random number table. The control group was given routine treatment method combined with naloxone hydrochloride injection for treatment, while the treatment group was additionally given Niuhuang Qingxin pills. Observed the changes of national institute of health stroke scale （NIHSS）, Glasgow coma scale （GCS） and Chinese medicine syndrome scores before and after treatment, compared and analyzed the clinical effect in the two groups, and detected the levels of S-100B and NPY in serum of the two groups before and after treatment. Results： After treatment, the NIHSS scores in the two groups were decreased when compared with those before treatment （P 〈 0.01）, and the GCS scores were increased when compared with those before treatment （P 〈 0.01）. The NIHSS score in the treatment group was lower than that in the control group （P 〈 0.01）, and its GCS score was higher than that in the control group （P 〈 0.01）. After treatment, the scores of light headedness, hemianesthesia, dry stool or constipation and abundant phlegm in the two groups were decreased when compared with those those before treatment （P 〈 0.01）. The four TCM syndrome scores mentioned above in the treatment group were lower than those in the control group （P 〈 0.01）. The total effective rate was 74.42% in the treatment group and 55.81% in the control group, difference being significant （P 〈 0.05）. After treatment, the levels of S-100B and NPY in serum of the two groups were decreased when compared with those before treatment （P 〈 0.01）. The levels of S-100B and NPY in serum of the treatment group were lower than those in the control group （P 〈 0.01）. Conclusion： The application of Niuhuang Qingxin pills in adjuvant treatment for acute cerebral hemorrhage can improve the nerve function and states of consciousness of patients and promote the curative effect. The mechanism may be related to the regulation of S-IOOB and NPY levels in vivo.
作者
沈海平
易昌容
SHEN Haiping;YI Changrong
出处
《新中医》
CAS
2018年第11期59-62,共4页
New Chinese Medicine
